ArticleMolecular and cellular biology2004
Mouse strains with an active H2-Ea meiotic recombination hot spot exhibit increased levels of H2-Ea-specific DNA breaks in testicular germ cells.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Advances Towards How Meiotic Recombination Is Initiated: A Comparative View and Perspectives for Plant Meiosis Research.International journal of molecular sciences · 2019Review
- Chromatin architecture may dictate the target site for DMC1, but not for RAD51, during homologous pairing.Scientific reports · 2016Article
- Natural polymorphisms in Tap2 influence negative selection and CD4∶CD8 lineage commitment in the rat.PLoS genetics · 2014Article
- New and old ways to control meiotic recombination.Trends in genetics : TIG · 2011Review
- Article
- Meiotic recombination protein Rec12: functional conservation, crossover homeostasis and early crossover/non-crossover decision.Nucleic acids research · 2011Article
- Initiation of meiotic recombination in mammals.Genes · 2010Article
- Nucleosome occupancy landscape and dynamics at mouse recombination hotspots.EMBO reports · 2010Article
- Oogenesis and cell death in human prenatal ovaries: what are the criteria for oocyte selection?Molecular human reproduction · 2009Article
- Spo11 and the Formation of DNA Double-Strand Breaks in Meiosis.Genome dynamics and stability · 2008Article
- Cis- and trans-acting elements regulate the mouse Psmb9 meiotic recombination hotspot.PLoS genetics · 2007Article
- Assessing human germ-cell mutagenesis in the Postgenome Era: a celebration of the legacy of William Lawson (Bill) Russell.Environmental and molecular mutagenesis · 2007Article
- Regulating double-stranded DNA break repair towards crossover or non-crossover during mammalian meiosis.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2007Review
- Distinct DNA-damage-dependent and -independent responses drive the loss of oocytes in recombination-defective mouse mutants.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
We devised a sensitive method for the site-specific detection of rare meiotic DNA strand breaks in germ cell-enriched testicular cell populations from mice that possess or lack an active recombination hot spot at the H2-Ea gene. Using germ cells from adult animals, we found an excellent correlation between the frequency of DNA breaks in the 418-bp H2-Ea hot spot and crossover activity. The temporal appearance of DNA breaks was also studied in 7- to 18-day-old mice with an active hot spot during the first waves of spermatogenesis. The number of DNA breaks detected rose as leptotene and zygotene spermatocytes populate the testis with a peak at day 14 postpartum, when leptotene, zygotene, and early pachytene spermatocytes are the most common meiotic prophase I cell types. The number of DNA breaks drops precipitously 1 day later, when middle to late pachytene spermatocytes become the dominant subtype. The recombination-related breaks in the hot spot likely reflect SPO11-induced double-strand breaks and/or recombination intermediates containing free 3' hydroxyl groups.
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Registered trials
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