Evidence map›Paper›PMID 14748924›Full record

ReviewRespiratory research2003

Association studies for asthma and atopic diseases: a comprehensive review of the literature.

Sabine Hoffjan, Dan Nicolae, Carole Ober

Registry-linked trialAbstract readReview
In one paragraph

Review in Respiratory research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00006512 (Characterizing a 5P-Linked BHR Susceptibility Locus), which is not on this map. Cited by 53 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00006512 completednot on this map

Characterizing a 5P-Linked BHR Susceptibility Locus

TypeobservationalSponsorUniversity of ChicagoRan2000 to 2005ConditionsAsthma, Lung Diseases
3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Association between Small Fetuses and Puberty Timing: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2017
    Pooled it
  2. Association of PAEs with Precocious Puberty in Children: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2015
    Pooled it
  3. Trial
  4. Trial
  5. Targeting alarmins in asthma: From bench to clinic.The Journal of allergy and clinical immunology · 2025
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Mutations in the filaggrin gene and food allergy.Przeglad gastroenterologiczny · 2014
    Review
  16. Genetic polymorphisms and associated susceptibility to asthma.International journal of general medicine · 2013
    Article
  17. Review
  18. Familial aggregation of allergen-specific sensitization and asthma.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2012
    Article
  19. A SOCS-1 promoter variant is associated with total serum IgE levels.Journal of immunology (Baltimore, Md. : 1950) · 2011
    Article
  20. Regulating the Regulators: microRNA and Asthma.The World Allergy Organization journal · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sabine HoffjanDepartment of Human Genetics, The University of Chicago, Chicago, IL 60637, USA.
Dan Nicolae
Carole Ober

Funding

Virus-Bacterial Interactions and Exacerba of AsthmaP01HL070831 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI GERN, JAMES E. · 2002 to 2017
$31.3M
T CELL CO-STIMULATION IN ALLERGIC ASTHMAP50HL056399 · NHLBI · UNIVERSITY OF CHICAGO · PI WHITE, STEVEN R · 1996 to 2005
$9.1M
Positional Cloning of a 6p-linked Asthma GeneR01HL072414 · NHLBI · UNIVERSITY OF CHICAGO · PI OBER, CAROLE · 2003 to 2007
$3.0M
CHARACTERIZING A 5P-LINKED BHR SUSCEPTIBILITY LOCUSR01HL066533 · NHLBI · UNIVERSITY OF CHICAGO · PI OBER, CAROLE · 2000 to 2004
$2.4M
NHLBI NIH HHS HL56399NHLBI NIH HHS HL66533NHLBI NIH HHS HL70831NHLBI NIH HHS HL72414NHLBI NIH HHS P01 HL070831NHLBI NIH HHS P50 HL056399NHLBI NIH HHS R01 HL066533NHLBI NIH HHS R01 HL072414
6 · The paper itself

Abstract

Hundreds of genetic association studies on asthma-related phenotypes have been conducted in different populations. To date, variants in 64 genes have been reported to be associated with asthma or related traits in at least one study. Of these, 33 associations were replicated in a second study, 9 associations were not replicated either in a second study or a second sample in the same study, and 22 associations were reported in just a single published study. These results suggest the potential for a great amount of heterogeneity underlying asthma. However, many of these studies are methodologically limited and their interpretation hampered by small sample sizes.

Indexed as

AsthmaGenetic VariationHumansHypersensitivityPhenotype

Identifiers

PMID14748924
PMCPMC314398

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.