ArticleGenetic epidemiology2004
IL10 gene polymorphisms are associated with asthma phenotypes in children.
Article in Genetic epidemiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 100 citations in OpenAlex.
- Interleukin-10 promoter gene polymorphisms and susceptibility to tuberculosis: a meta-analysis.PloS one · 2015Pooled it
- Pooled it
- Interleukin-10 promoter gene polymorphisms and susceptibility to asthma: a meta-analysis.PloS one · 2013Pooled it
- Mother's smoking habits affects IL10 methylation but not asthma in Ecuadorian children.Molecular genetics & genomic medicine · 2024Article
- Genome-wide mapping of gene-microbe interactions in the murine lung microbiota based on quantitative microbial profiling.Animal microbiome · 2023Article
- Association between IL-10 (at position -592) and IL-4 (at position -589) genotype polymorphism with atopic and non-atopic asthma in children.American journal of clinical and experimental immunology · 2023Article
- Gestational hypertension and childhood atopy: a Millennium Cohort Study analysis.European journal of pediatrics · 2021Article
- Article
- Prevalence and risk factors for asthma, rhinitis, eczema, and atopy among preschool children in an Andean city.PloS one · 2020Article
- Polymorphisms in the promoter region of IL10 gene are associated with virus etiology of infant bronchiolitis.World journal of pediatrics : WJP · 2018Article
- The Study ofTanaffos · 2018Article
- Testing Allele Transmission of an SNP Set Using a Family-Based Generalized Genetic Random Field Method.Genetic epidemiology · 2016Article
- Article
- A powerful nonparametric statistical framework for family-based association analyses.Genetics · 2015Article
- IL-10 Gene Polymorphisms Are Associated with Post-Bronchiolitis Lung Function Abnormalities at Six Years of Age.PloS one · 2015Article
- Allergic asthma biomarkers using systems approaches.Frontiers in genetics · 2014Review
- Interleukin 10 (IL10) and transforming growth factor β1 (TGFβ1) gene polymorphisms in persistent IgE-mediated cow's milk allergy.Clinics (Sao Paulo, Brazil) · 2013Article
- Outcome vector dependent sampling with longitudinal continuous response data: stratified sampling based on summary statistics.Biometrics · 2013Article
- Human "orchestrator" CD11b(+) B1 cells spontaneously secrete interleukin-10 and regulate T-cell activity.Molecular medicine (Cambridge, Mass.) · 2012Article
- Updates on the COPD gene list.International journal of chronic obstructive pulmonary disease · 2012Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
IL10 is an anti-inflammatory cytokine that has been found to have lower production in macrophages and mononuclear cells from asthmatics. Since reduced IL10 levels may influence the severity of asthma phenotypes, we examined IL10 single-nucleotide polymorphisms (SNPs) for association with asthma severity and allergy phenotypes as quantitative traits. Utilizing DNA samples from 518 Caucasian asthmatic children from the Childhood Asthma Management Program (CAMP) and their parents, we genotyped six IL10 SNPs: 3 in the promoter, 2 in introns, and one in the 3' UTR. Using family-based association tests, each SNP was tested for association with asthma and allergy phenotypes individually. Population-based association analysis was performed with each SNP locus, the promoter haplotypes and the 6-loci haplotypes. The 3' UTR SNP was significantly associated with FEV(1) as a percent of predicted (FEV(1)PP) (P=0.0002) in both the family and population analyses. The promoter haplotype GCC was positively associated with IgE levels and FEV(1)PP (P=0.007 and 0.012, respectively). The promoter haplotype ATA was negatively associated with lnPC(20) and FEV(1)PP (P=0.008 and 0.043, respectively). Polymorphisms in IL10 are associated with asthma phenotypes in this cohort. Further studies of variation in the IL10 gene may help elucidate the mechanism of asthma development in children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.