ArticleLearning & memory (Cold Spring Harbor, N.Y.)
Perirhinal cortex muscarinic receptor blockade impairs taste recognition memory formation.
Article in Learning & memory (Cold Spring Harbor, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 31 citations in OpenAlex.
- Scopolamine infusion in the basolateral amygdala after saccharin intake induces conditioned taste avoidance in rats.Psychopharmacology · 2024Article
- Expression of c-Fos following voluntary ingestion of a novel or familiar taste in rats.Brain research · 2023Article
- The consolidation of object and context recognition memory involve different regions of the temporal lobe.Learning & memory (Cold Spring Harbor, N.Y.) · 2008Article
- Muscarinic control of long-range GABAergic inhibition within the rhinal cortices.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Coantagonism of glutamate receptors and nicotinic acetylcholinergic receptors disrupts fear conditioning and latent inhibition of fear conditioning.Learning & memory (Cold Spring Harbor, N.Y.)Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relevance of perirhinal cortical cholinergic and glutamatergic neurotransmission for taste recognition memory and learned taste aversion was assessed by microinfusions of muscarinic (scopolamine), NMDA (AP-5), and AMPA (NBQX) receptor antagonists. Infusions of scopolamine, but not AP5 or NBQX, prevented the consolidation of taste recognition memory using attenuation of neophobia as an index. In addition, learned taste aversion in both short- and long-term memory tests was exclusively impaired by scopolamine. These data provide neurochemical support for the theory that cholinergic activity of the perirhinal cortex participates in the formation of the taste memory trace and that it is independent of the NMDA and AMPA receptor activity. These results support the idea that cholinergic neurotransmission in the perirhinal cortex is also essential for acquisition and consolidation of taste recognition memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.