ReviewLearning & memory (Cold Spring Harbor, N.Y.)
Septohippocampal acetylcholine: involved in but not necessary for learning and memory?
Review in Learning & memory (Cold Spring Harbor, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed.
- Cholinergic enhancement of episodic memory in healthy young adults.Psychopharmacology · 2005Trial
- Cholinergic modulation of rearing in rats performing a spatial memory task.The European journal of neuroscience · 2024Article
- Septohippocampal cholinergic system at the intersection of stress and cognition: Current trends and translational implications.The European journal of neuroscience · 2024Review
- Switching between External and Internal Attention in Hippocampal Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
- Protective Effects of a synthetic glycosaminoglycan mimetic (OTR4132) in a rat immunotoxic lesion model of septohippocampal cholinergic degeneration.Glycoconjugate journal · 2022Article
- Long lasting effect of acute restraint stress on behavior and brain anti-oxidative status.AIMS neuroscience · 2022Article
- Intrahippocampal blockade of nicotinic or muscarinic receptors fails to impair nonnavigational spatial memory in macaques.Behavioral neuroscience · 2021Article
- Synergistic protective effect of Beta vulgaris with meso-2,3-dimercaptosuccinic acid against lead-induced neurotoxicity in male rats.Scientific reports · 2021Article
- Evaluation of the Activity of Choline Acetyltransferase From Different Synaptosomal Fractions at the Distinct Stages of Spatial Learning in the Morris Water Maze.Frontiers in behavioral neuroscience · 2021Article
- Modulation of spatial memory and expression of hippocampal neurotransmitter receptors by selective lesion of medial septal cholinergic and GABAergic neurons.Experimental brain research · 2020Article
- The effects of crocin on spatial memory impairment induced by hyoscine: Role of NMDA, AMPA, ERK, and CaMKII proteins in rat hippocampus.Iranian journal of basic medical sciences · 2019Article
- Computational insight to putative anti-acetylcholinesterase activity ofIn silico pharmacology · 2019Article
- Impaired object-location learning and recognition memory but enhanced sustained attention in M2 muscarinic receptor-deficient mice.Psychopharmacology · 2018Article
- Terminalia chebula extract prevents scopolamine-induced amnesia via cholinergic modulation and anti-oxidative effects in mice.BMC complementary and alternative medicine · 2018Article
- Acetylcholine contributes to the integration of self-movement cues in head direction cells.Behavioral neuroscience · 2017Article
- Interaction between age and perceptual similarity in olfactory discrimination learning in F344 rats: relationships with spatial learning.Neurobiology of aging · 2017Article
- The Cholinergic System Modulates Memory and Hippocampal PlasticityFrontiers in immunology · 2017Review
- Navigating Monogamy: Nonapeptide Sensitivity in a Memory Neural Circuit May Shape Social Behavior and Mating Decisions.Frontiers in neuroscience · 2017Review
- Modulation of Hippocampal Circuits by Muscarinic and Nicotinic Receptors.Frontiers in neural circuits · 2017Review
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The neurotransmitter acetylcholine (ACh) has been accorded an important role in supporting learning and memory processes in the hippocampus. Cholinergic activity in the hippocampus is correlated with memory, and restoration of ACh in the hippocampus after disruption of the septohippocampal pathway is sufficient to rescue memory. However, selective ablation of cholinergic septohippocampal projections is largely without effect on hippocampal-dependent learning and memory processes. We consider the evidence underlying each of these statements, and the contradictions they pose for understanding the functional role of hippocampal ACh in memory. We suggest that although hippocampal ACh is involved in memory in the intact brain, it is not necessary for many aspects of hippocampal memory function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.