ArticleJournal of clinical pathology2004
Infection of the CNS by Scedosporium apiospermum after near drowning. Report of a fatal case and analysis of its confounding factors.
Article in Journal of clinical pathology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 53 citations in OpenAlex.
- Pulmonary Infiltrates in a Non-Cystic Fibrosis Bronchiectasis Patient: A Case Report.Journal of clinical medicine · 2025Article
- Multi-organ involvement caused by Scedosporium apiospermum infection after near drowning: a case report and literature review.BMC neurology · 2024Review
- Fungal Infections in Liver Transplant Recipients.Journal of fungi (Basel, Switzerland) · 2021Review
- Management of pulmonaryThe Journal of international medical research · 2020Article
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- Scedosporiosis in a Combined Kidney and Liver Transplant Recipient: A Case Report of Possible Transmission from a Near-Drowning Donor.Case reports in transplantation · 2016Article
- The importance of a proper aetiological diagnosis in the management of patients with invasive mycoses: a case report of a brain abscess by Scedosporium apiospermum.Mycopathologia · 2011Article
- Experimental murine scedosporiosis: histopathology and azole treatment.Antimicrobial agents and chemotherapy · 2010Article
- Tracking the emerging human pathogen Pseudallescheria boydii by using highly specific monoclonal antibodies.Clinical and vaccine immunology : CVI · 2009Article
- Infections caused by Scedosporium spp.Clinical microbiology reviews · 2008Review
- Antifungal susceptibilities of the species of the Pseudallescheria boydii complex.Antimicrobial agents and chemotherapy · 2006Article
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Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This report describes a fatal case of central nervous system pseudallescheriasis. A 32 year old white man presented with headache and meningismus 15 days after nearly drowning in a swine sewage reservoir. Computerised tomography and magnetic resonance imaging of the head revealed multiple brain granulomata, which vanished when steroid and broad spectrum antimicrobial and antifungal agents, in addition to dexamethasone, were started. Cerebrospinal fluid analysis disclosed a neutrophilic meningitis. Treatment with antibiotics and amphotericin B, together with fluconazole and later itraconazole, was ineffective. Miconazole was added through an Ommaya reservoir, but was insufficient to halt the infection. Pseudallescheria boydii was finally isolated and identified in cerebrospinal fluid cultures, a few days before death, three and a half months after the symptoms began. Diagnosis was delayed because of a reduction in the lesions after partial treatment, which prevented a stereotactic biopsy. Physicians should be aware of this condition, and provide prompt stereotactic biopsy. Confirmed cases should perhaps be treated with voriconazole, probably the most effective, currently available treatment for this agent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.