ArticleBiophysical journal2004
Sensitivity of second harmonic generation from styryl dyes to transmembrane potential.
Article in Biophysical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Confinement of a Styryl Dye into Nanoporous Aluminophosphates: Channels vs. Cavities.International journal of molecular sciences · 2024Article
- Harmonic Generation Microscopy 2.0: New Tricks Empowering Intravital Imaging for Neuroscience.Frontiers in molecular biosciences · 2019Review
- Multimodal two-photon imaging using a second harmonic generation-specific dye.Nature communications · 2016Article
- Differential effect of plant lipids on membrane organization: specificities of phytosphingolipids and phytosterols.The Journal of biological chemistry · 2015Article
- Improved PeT molecules for optically sensing voltage in neurons.Journal of the American Chemical Society · 2015Article
- QM/MM studies of contemporary and novel membrane raft fluorescent probes.Molecules (Basel, Switzerland) · 2014Article
- Engineering a genetically-encoded SHG chromophore by electrostatic targeting to the membrane.Frontiers in molecular neuroscience · 2014Article
- Porphyrins for probing electrical potential across lipid bilayer membranes by second harmonic generation.Angewandte Chemie (International ed. in English) · 2013Article
- Precise, motion-free polarization control in Second Harmonic Generation microscopy using a liquid crystal modulator in the infinity space.Biomedical optics express · 2013Article
- Surface functionalization of barium titanate SHG nanoprobes for in vivo imaging in zebrafish.Nature protocols · 2012Article
- In vivo imaging of myelin in the vertebrate central nervous system using third harmonic generation microscopy.Biophysical journal · 2011Article
- Fluorescence techniques for determination of the membrane potentials in high throughput screening.Journal of fluorescence · 2010Review
- Role of membrane potential in the regulation of cell proliferation and differentiation.Stem cell reviews and reports · 2009Review
- Monitoring biophysical properties of lipid membranes by environment-sensitive fluorescent probes.Biophysical journal · 2009Review
- Cardiovascular imaging using two-photon microscopy.Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada · 2008Review
- Amino(oligo)thiophene-based environmentally sensitive biomembrane chromophores.The Journal of organic chemistry · 2008Article
- Analysis of ligand binding to a ribose biosensor using site-directed mutagenesis and fluorescence spectroscopy.Protein science : a publication of the Protein Society · 2007Article
- Imaging membrane potential in dendrites and axons of single neurons.Pflugers Archiv : European journal of physiology · 2006Review
- Characterization and application of a new optical probe for membrane lipid domains.Biophysical journal · 2006Article
- Characterization of the myosin-based source for second-harmonic generation from muscle sarcomeres.Biophysical journal · 2006Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
In this article we present results from the simultaneous nonlinear (second harmonic generation and two-photon excitation fluorescence) imaging and voltage clamping of living cells. Specifically, we determine the sensitivity to transmembrane potential of second harmonic generation by ANEP-chromophore styryl dyes as a function of excitation wavelength and dye structure. We have measured second harmonic sensitivities of up to 43% per 100 mV, more than a factor of four better than the nominal voltage sensitivity of the dyes under "one-photon" fluorescence. We find a dependence of voltage sensitivity on excitation wavelength that is consistent with a two-photon resonance, and there is a significant dependence of voltage sensitivity on the structure of the nonchromophore portion of the dyes.
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Registered trials
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