ArticleBiophysical journal2004
Conduction mechanisms of chloride ions in ClC-type channels.
Article in Biophysical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 75 citations in OpenAlex.
- Thermodynamics and Kinetics of Ion Permeation in Wild-Type and Mutated Open Active Conformation of the Human α7 Nicotinic Receptor.Journal of chemical information and modeling · 2020Article
- Chloride Ion Transport by theFrontiers in chemistry · 2018Article
- ClC-1 and ClC-2 form hetero-dimeric channels with novel protopore functions.Pflugers Archiv : European journal of physiology · 2014Article
- Modeling and simulation of ion channels.Chemical reviews · 2012Review
- Influences of mutations on the electrostatic binding free energies of chloride ions in Escherichia coli ClC.The journal of physical chemistry. B · 2012Article
- Permeation and block of the Kv1.2 channel examined using brownian and molecular dynamics.Biophysical journal · 2011Article
- Testing the applicability of Nernst-Planck theory in ion channels: comparisons with Brownian dynamics simulations.PloS one · 2011Article
- An improved open-channel structure of MscL determined from FRET confocal microscopy and simulation.The Journal of general physiology · 2010Article
- Synthetic chloride-selective carbon nanotubes examined by using molecular and stochastic dynamics.Biophysical journal · 2010Article
- A three-state multi-ion kinetic model for conduction properties of ClC-0 chloride channel.Biophysical journal · 2010Article
- Permeant anions contribute to voltage dependence of ClC-2 chloride channel by interacting with the protopore gate.The Journal of physiology · 2010Article
- Secondary water pore formation for proton transport in a ClC exchanger revealed by an atomistic molecular-dynamics simulation.Biophysical journal · 2010Article
- Ion conduction in ligand-gated ion channels: Brownian dynamics studies of four recent crystal structures.Biophysical journal · 2010Article
- Computational study of the transmembrane domain of the acetylcholine receptor.European biophysics journal : EBJ · 2009Article
- Voltage-dependent and -independent titration of specific residues accounts for complex gating of a ClC chloride channel by extracellular protons.The Journal of physiology · 2009Article
- Computational prediction of ion permeation characteristics in the glycine receptor modified by photo-sensitive compounds.Journal of computer-aided molecular design · 2008Article
- The role of a conserved lysine in chloride- and voltage-dependent ClC-0 fast gating.The Journal of general physiology · 2007Article
- Evaluation of the membrane-spanning domain of ClC-2.The Biochemical journal · 2006Article
- Roles of K149, G352, and H401 in the channel functions of ClC-0: testing the predictions from theoretical calculations.The Journal of general physiology · 2006Article
- Diversity of Cl(-) channels.Cellular and molecular life sciences : CMLS · 2006Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The conduction properties of ClC-0 and ClC-1 chloride channels are examined using electrostatic calculations and three-dimensional Brownian dynamics simulations. We create an open-state configuration of the prokaryotic ClC Cl(-) channel using its known crystallographic structure as a basis. Two residues that are occluding the channel are slowly pushed outward with molecular dynamics to create a continuous ion-conducting path with the minimum radius of 2.5 A. Then, retaining the same pore shape, the prokaryotic ClC channel is converted to either ClC-0 or ClC-1 by replacing all the nonconserved dipole-containing and charged amino acid residues. Employing open-state ClC-0 and ClC-1 channel models, current-voltage curves consistent with experimental measurements are obtained. We find that conduction in these pores involves three ions. We locate the binding sites, as well as pinpointing the rate-limiting steps in conduction, and make testable predictions about how the single channel current across ClC-0 and ClC-1 will vary as the ionic concentrations are increased. Finally, we demonstrate that a ClC-0 homology model created from an alternative sequence alignment fails to replicate any of the experimental observations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.