ArticleJournal of molecular evolution2003
Selection for highly biased amino acid frequency in the TolA cell envelope protein of Proteobacteria.
Article in Journal of molecular evolution, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- The GC Content as a Main Factor Shaping the Amino Acid Usage During Bacterial Evolution Process.Frontiers in microbiology · 2018Article
- Molecular evolution of NASP and conserved histone H3/H4 transport pathway.BMC evolutionary biology · 2014Article
- Article
- Evolutionary dynamics of the 5S rDNA gene family in the mussel Mytilus: mixed effects of birth-and-death and concerted evolution.Journal of molecular evolution · 2010Article
- Molecular phylogeny, long-term evolution, and functional divergence of flavin-containing monooxygenases.Genetica · 2009Article
- The evolutionary differentiation of two histone H2A.Z variants in chordates (H2A.Z-1 and H2A.Z-2) is mediated by a stepwise mutation process that affects three amino acid residues.BMC evolutionary biology · 2009Article
- Early evolution of histone genes: prevalence of an 'orphon' H1 lineage in protostomes and birth-and-death process in the H2A family.Journal of molecular evolution · 2008Article
- Long-term evolution and functional diversification in the members of the nucleophosmin/nucleoplasmin family of nuclear chaperones.Genetics · 2006Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The bacterial cell envelope protein TolA functions to maintain the integrity of the cell membrane. This protein contains high levels of alanine and lysine that are used in the formation of alpha helices, which are required for normal protein function. The neutral model of molecular evolution predicts that amino acid composition and nucleotide composition are driven by the underlying GC content, as a result of mutation bias. However, this study shows that selection has acted to maintain high levels of alanine and lysine in the TolA protein of Proteobacteria, which in turn has biased nucleotide composition in the corresponding tolA gene.
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