ArticleMolecular psychiatry2004
Association study of an SNP combination pattern in the dopaminergic pathway in paranoid schizophrenia: a novel strategy for complex disorders.
Article in Molecular psychiatry, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 41 citations in OpenAlex.
- Separate and interacting effects within the catechol-O-methyltransferase (COMT) are associated with schizophrenia.Molecular psychiatry · 2005Trial
- Dopaminergic Epistases in Schizophrenia.Brain sciences · 2024Review
- Toward a phenomic analysis of chronic postsurgical pain following cardiac surgery.Canadian journal of pain = Revue canadienne de la douleur · 2019Article
- Modulation of monoamine oxidase (MAO) expression in neuropsychiatric disorders: genetic and environmental factors involved in type A MAO expression.Journal of neural transmission (Vienna, Austria : 1996) · 2016Review
- Aldehyde dehydrogenases in cellular responses to oxidative/electrophilic stress.Free radical biology & medicine · 2013Review
- Effects of MAOA promoter methylation on susceptibility to paranoid schizophrenia.Human genetics · 2012Article
- Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily.Expert opinion on drug metabolism & toxicology · 2008Review
- Analysis of phenotype-genotype connection: the story of dissecting disease pathogenesis in genomic era in China, and beyond.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2007Review
- Expression and initial characterization of human ALDH3B1.Biochemical and biophysical research communications · 2007Article
- Identification of expression quantitative trait loci by the interaction analysis using genetic algorithm.BMC proceedings · 2007Article
- Genetics, transcriptomics, and proteomics of Alzheimer's disease.The Journal of clinical psychiatry · 2006Review
- Genetic tests of biologic systems in affective disorders.Molecular psychiatry · 2005Review
- Complex disorders reloaded: causality, action, reaction, cause and effect.Molecular psychiatry · 2004Article
- ALDH3B1 Is an Independent Prognostic Biomarker of Lung Adenocarcinoma.Technology in cancer research & treatmentArticle
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
21 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia is a common mental disorder with a complex pattern of inheritance. Despite a large number of studies in the past decades, its molecular etiology remains unknown. In this study, we proposed a 'system-thinking' strategy in seeking the combined effect of susceptibility genes for a complex disorder by using paranoid schizophrenia as an example. We genotyped 85 reported single-nucleotide polymorphisms (SNPs) present in 23 genes for the dopamine (DA) metabolism pathway among 83 paranoid schizophrenics and 108 normal controls with detailed clinical and genetic information. We developed two novel multilocus approaches-the potential effective SNP combination pattern and potential effective dynamic effects analysis, by which three susceptibility genotype combinations were found to be associated with schizophrenia. These results were also validated in a family-based cohort consisting of 95 family trios of paranoid schizophrenia. The present findings suggest that the COMT and ALDH3 combination may be the most common type involved in predisposing to schizophrenia. Since the combination blocks the whole pathways for the breakdown of DA and noradrenaline, it is very likely to play a central role in developing paranoid schizophrenia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.