ArticleProceedings of the National Academy of Sciences of the United States of America2004
Evolution of the MAT locus and its Ho endonuclease in yeast species.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.
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100 citing papers in PubMed.
- Review
- Repeated losses of self-fertility shaped heterozygosity and polyploidy in yeast evolution.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Genetic and environmental control of parasexual reproduction in the pathogenicMicrobiology and molecular biology reviews : MMBR · 2025Review
- Review
- Functional and Evolutionary Integration of a Fungal Gene With a Bacterial Operon.Molecular biology and evolution · 2024Article
- Genome Analysis of a Newly Discovered Yeast Species,Journal of fungi (Basel, Switzerland) · 2024Article
- Structure of the Mating-Type Genes and Mating Systems ofJournal of fungi (Basel, Switzerland) · 2023Article
- Functional and evolutionary integration of a fungal gene with a bacterial operon.bioRxiv : the preprint server for biology · 2023Article
- Rapid evolutionary repair by secondary perturbation of a primary disrupted transcriptional network.EMBO reports · 2023Article
- Is There a Relationship Between Mating and Pathogenesis in Two Human Fungal Pathogens,Current clinical microbiology reports · 2023Review
- Article
- Population genomics of the grapevine pathogen Eutypa lata reveals evidence for population expansion and intraspecific differences in secondary metabolite gene clusters.PLoS genetics · 2022Article
- Genome analysis of five recently described species of the CUG-Ser clade uncovers Candida theae as a new hybrid lineage with pathogenic potential in the Candida parapsilosis species complex.DNA research : an international journal for rapid publication of reports on genes and genomes · 2022Article
- Insights on life cycle and cell identity regulatory circuits for unlocking genetic improvement in Zygosaccharomyces and Kluyveromyces yeasts.FEMS yeast research · 2021Article
- Lessons from the Nakaseomyces: mating-type switching, DSB repair and evolution of Ho.Current genetics · 2021Review
- Hybridization ofMicroorganisms · 2021Article
- Variable Spontaneous Mutation and Loss of Heterozygosity among Heterozygous Genomes in Yeast.Molecular biology and evolution · 2020Article
- A single Ho-induced double-strand break at the MAT locus is lethal in Candida glabrata.PLoS genetics · 2020Article
- Article
- Genome Assemblies of Two Rare Opportunistic Yeast Pathogens:G3 (Bethesda, Md.) · 2019Article
40 more citing papers are in PubMed but not listed here.
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The genetics of the mating-type (MAT) locus have been studied extensively in Saccharomyces cerevisiae, but relatively little is known about how this complex system evolved. We compared the organization of MAT and mating-type-like (MTL) loci in nine species spanning the hemiascomycete phylogenetic tree. We inferred that the system evolved in a two-step process in which silent HMR/HML cassettes appeared, followed by acquisition of the Ho endonuclease from a mobile genetic element. Ho-mediated switching between an active MAT locus and silent cassettes exists only in the Saccharomyces sensu stricto group and their closest relatives: Candida glabrata, Kluyveromyces delphensis, and Saccharomyces castellii. We identified C. glabrata MTL1 as the ortholog of the MAT locus of K. delphensis and show that switching between C. glabrata MTL1a and MTL1alpha genotypes occurs in vivo. The more distantly related species Kluyveromyces lactis has silent cassettes but switches mating type without the aid of Ho endonuclease. Very distantly related species such as Candida albicans and Yarrowia lipolytica do not have silent cassettes. In Pichia angusta, a homothallic species, we found MATalpha2, MATalpha1, and MATa1 genes adjacent to each other on the same chromosome. Although some continuity in the chromosomal location of the MAT locus can be traced throughout hemiascomycete evolution and even to Neurospora, the gene content of the locus has changed with the loss of an HMG domain gene (MATa2) from the MATa idiomorph shortly after HO was recruited.
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