ArticleProceedings of the National Academy of Sciences of the United States of America2004
Stem cell-mediated muscle regeneration is enhanced by local isoform of insulin-like growth factor 1.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
93 citing papers in PubMed, 245 citations in OpenAlex.
- Downstream Pathways of Dystrophin Deficiency in Duchenne Muscular Dystrophy: Implications for Muscle Degeneration and Regeneration.Journal of cachexia, sarcopenia and muscle · 2026Review
- Current Challenges and Future Directions in the Assessment of Glucocorticoid Status.Endocrine reviews · 2024Review
- Mending a broken heart by biomimetic 3D printed natural biomaterial-based cardiac patches: a review.Frontiers in bioengineering and biotechnology · 2023Review
- Long-Term Controlled Growth Factor Release Using Layer-by-Layer Assembly for the Development ofACS applied materials & interfaces · 2022Article
- Influence of IGF-I serum concentration on muscular regeneration capacity in patients with sarcopenia.BMC musculoskeletal disorders · 2021Article
- Exercise-Stimulated ROS Sensitive Signaling Pathways in Skeletal Muscle.Antioxidants (Basel, Switzerland) · 2021Review
- Blockade of IGF2R improves muscle regeneration and ameliorates Duchenne muscular dystrophy.EMBO molecular medicine · 2020Article
- Potential of Soluble Decellularized Extracellular Matrix for Musculoskeletal Tissue Engineering - Comparison of Various Mesenchymal Tissues.Frontiers in cell and developmental biology · 2020Article
- The factors present in regenerating muscles impact bone marrow-derived mesenchymal stromal/stem cell fusion with myoblasts.Stem cell research & therapy · 2019Article
- Effects of IGF-1 isoforms on muscle growth and sarcopenia.Aging cell · 2019Article
- Hang on tight: reprogramming the cell with microstructural cues.Biomedical microdevices · 2019Review
- Changes in Skeletal Muscle and Body Weight on Sleeping Beauty Transposon-Mediated Transgenic Mice Overexpressing Pig mIGF-1.Biochemical genetics · 2018Article
- Molecular Insights into Muscle Homeostasis, Atrophy and Wasting.Current genomics · 2018Review
- High final energy of gallium arsenide laser increases MyoD gene expression during the intermediate phase of muscle regeneration after cryoinjury in rats.Lasers in medical science · 2018Article
- The structure-function relationships of insulin-like growth factor 1 Ec in C2C12 cells.Cell adhesion & migration · 2018Article
- Italian consensus conference on guidelines for conservative treatment on lower limb muscle injuries in athlete.BMJ open sport & exercise medicine · 2018Article
- Neurotrophic and Neuroregenerative Effects of GH/IGF1.International journal of molecular sciences · 2017Review
- Keratin Hydrogel Enhances In Vivo Skeletal Muscle Function in a Rat Model of Volumetric Muscle Loss.Tissue engineering. Part A · 2017Article
- Different Effects of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor-2 on Myogenic Differentiation of Human Mesenchymal Stem Cells.Stem cells international · 2017Article
- Insulin-Like Growth Factor Binding Protein-6 Alters Skeletal Muscle Differentiation of Human Mesenchymal Stem Cells.Stem cells international · 2017Article
33 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
We investigated the mechanism whereby expression of a transgene encoding a locally acting isoform of insulin-like growth factor 1 (mIGF-1) enhances repair of skeletal muscle damage. Increased recruitment of proliferating bone marrow cells to injured MLC/mIgf-1 transgenic muscles was accompanied by elevated bone marrow stem cell production in response to distal trauma. Regenerating MLC/mIgf-1 transgenic muscles contained increased cell populations expressing stem cell markers, exhibited accelerated myogenic differentiation, expressed markers of regeneration and readily converted cocultured bone marrow to muscle. These data implicate mIGF-1 as a powerful enhancer of the regeneration response, mediating the recruitment of bone marrow cells to sites of tissue damage and augmenting local repair mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.