ArticleThe Journal of cell biology2004
WASp is required for the correct temporal morphogenesis of rhabdomere microvilli.
Article in The Journal of cell biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
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- Hydroxylated sphingolipid biosynthesis regulates photoreceptor apical domain morphogenesis.The Journal of cell biology · 2020Article
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- TheDevelopment (Cambridge, England) · 2018Article
- The Glide/Gcm fate determinant controls initiation of collective cell migration by regulating Frazzled.eLife · 2016Article
- Imaging the Drosophila retina: zwitterionic buffers PIPES and HEPES induce morphological artifacts in tissue fixation.BMC developmental biology · 2015Article
- N-WASP is required for Amphiphysin-2/BIN1-dependent nuclear positioning and triad organization in skeletal muscle and is involved in the pathophysiology of centronuclear myopathy.EMBO molecular medicine · 2014Article
- chaoptin, prominin, eyes shut and crumbs form a genetic network controlling the apical compartment of Drosophila photoreceptor cells.Biology open · 2014Article
- Developmental expression of Drosophila Wiskott-Aldrich Syndrome family proteins.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
- Pph13 and orthodenticle define a dual regulatory pathway for photoreceptor cell morphogenesis and function.Development (Cambridge, England) · 2010Article
- Building a fly eye: terminal differentiation events of the retina, corneal lens, and pigmented epithelia.Current topics in developmental biology · 2010Review
- Wash functions downstream of Rho and links linear and branched actin nucleation factors.Development (Cambridge, England) · 2009Article
- Amphiphysin 1 is important for actin polymerization during phagocytosis.Molecular biology of the cell · 2007Article
- Protein kinase D regulates several aspects of development in Drosophila melanogaster.BMC developmental biology · 2007Article
- Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Microvilli are actin-based fingerlike membrane projections that form the basis of the brush border of enterocytes and the Drosophila melanogaster photoreceptor rhabdomere. Although many microvillar cytoskeletal components have been identified, the molecular basis of microvillus formation is largely undefined. Here, we report that the Wiskott-Aldrich syndrome protein (WASp) is necessary for rhabdomere microvillus morphogenesis. We show that WASp accumulates on the photoreceptor apical surface before microvillus formation, and at the time of microvillus initiation WASp colocalizes with amphiphysin and moesin. The loss of WASp delays the enrichment of F-actin on the apical photoreceptor surface, delays the appearance of the primordial microvillar projections, and subsequently leads to malformed rhabdomeres.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.