Evidence map›Paper›PMID 14744823›Full record

ArticleBMJ (Clinical research ed.)2004

Population based study of early risk of stroke after transient ischaemic attack or minor stroke: implications for public education and organisation of services.

A J Coull, J K Lovett, P M Rothwell, Oxford Vascular Study

3 registry-linked trialsAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ (Clinical research ed.), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 220 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
220citing papers in PubMed, 17 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00553241 unknown statusnot on this mapstarted 2007, after this paper: background citation

Phase 1 of Clinical Trial of Risk Factor, Prognosis, Imaging and Standard Management of Transient Ischemic Attack.

TypeobservationalSponsorCapital Medical UniversityRan2007 to 2009Enrolled1ConditionsIschemic Attack, Transient
NCT00991029 phase3terminatednot on this mapstarted 2010, after this paper: background citation

Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trial

TypeinterventionalSponsorUniversity of California, San FranciscoRan2010 to 2018Enrolled4,881ConditionsIschemic Attack, TransientArmsClopidogrel, placebo
NCT05310968 phase4completednot on this mapstarted 2022, after this paper: background citation

Study on Tirofiban With Aspirin in the Treatment of Acute Penetrating Artery Territory Infarction (STRATEGY)

TypeinterventionalSponsorBeijing Tiantan HospitalRan2022 to 2025Enrolled970ConditionsBranch Atheromatous DiseaseArmsTirofiban hydrochloride sodium chloride injection, Tirofiban hydrochloride sodium chloride injection placebo, Aspirin
3 · Its place in the literature

Who cites it

220 citing papers in PubMed, 17 syntheses or guidelines pooled it.

  1. Interaction of CYP2C19 with the effect of clopidogrel in secondary prevention of major ischemic events: Systematic review and meta-analysis.International journal of stroke : official journal of the International Stroke Society · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. The role ofExpert review of clinical pharmacology · 2022
    Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Pooled it
  15. Pooled it
  16. Guideline
  17. Pooled it
  18. Trial
  19. Differential effect of ticagrelor versus clopidogrel by homocysteine levels on risk of recurrent stroke: a post hoc analysis of the CHANCE-2 trial.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2024
    Trial
  20. Trial

160 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

A J CoullStroke Prevention Research Unit, Department of Clinical Neurology, Radcliffe Infirmary, Oxford OX2 6HE.
J K Lovett
P M Rothwell
Oxford Vascular Study

Funding

Medical Research Council G0500987
6 · The paper itself

Abstract

objectiveTo estimate the very early stroke risk after a transient ischaemic attack (TIA) or minor stroke and thereby inform the planning of effective stroke prevention services.

designPopulation based prospective cohort study of patients with TIA or stroke.

settingNine general practices in Oxfordshire, England, from April 2002 to April 2003.

participantsAll patients who had a TIA (n = 87) or minor stroke (n = 87) during the study period and who presented to medical attention.

main outcome measuresRisk of recurrent stroke at seven days, one month, and three months after TIAs and minor strokes.

resultsThe estimated risk of recurrent stroke was 8.0% (95% confidence interval 2.3% to 13.7%) at seven days, 11.5% (4.8% to 18.2%) at one month, and 17.3% (9.3% to 25.3%) at three months after a TIA. The risks at these three time periods after a minor stroke were 11.5% (4.8% to 11.2%), 15.0% (7.5% to 22.5%), and 18.5% (10.3% to 26.7%).

conclusionsThe early risks of stroke after a TIA or minor stroke are much higher than commonly quoted. More research is needed to determine whether these risks can be reduced by more rapid instigation of preventive treatment.

Indexed as

AgedCohort StudiesFemaleHumansIschemic Attack, TransientMaleProspective StudiesRecurrenceRisk FactorsStroke

Identifiers

PMID14744823
PMCPMC338101

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.