ArticleJournal of molecular neuroscience : MN2004
Kalirin expression is regulated by multiple promoters.
Article in Journal of molecular neuroscience : MN, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Review
- Alternate promoter usage generates two subpopulations of the neuronal RhoGEF Kalirin-7.Journal of neurochemistry · 2017Article
- A Novel Long Non-coding RNA,Frontiers in molecular neuroscience · 2017Article
- Reversing synapse loss in Alzheimer's disease: Rho-guanosine triphosphatases and insights from other brain disorders.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2015Review
- Elimination of Kalrn expression in POMC cells reduces anxiety-like behavior and contextual fear learning.Hormones and behavior · 2014Article
- Nonenzymatic domains of Kalirin7 contribute to spine morphogenesis through interactions with phosphoinositides and Abl.Molecular biology of the cell · 2014Article
- Article
- Kalrn plays key roles within and outside of the nervous system.BMC neuroscience · 2012Article
- SynGAP isoforms exert opposing effects on synaptic strength.Nature communications · 2012Article
- Kalirin, a key player in synapse formation, is implicated in human diseases.Neural plasticity · 2012Review
- Kalrn promoter usage and isoform expression respond to chronic cocaine exposure.BMC neuroscience · 2011Article
- Synaptic plasticity, a symphony in GEF.ACS chemical neuroscience · 2010Article
- Kalirin: a novel genetic risk factor for ischemic stroke.Human genetics · 2010Article
- Autonomous functions for the Sec14p/spectrin-repeat region of Kalirin.Experimental cell research · 2008Article
- Genetics of premature myocardial infarction.Current atherosclerosis reports · 2008Review
- Peakwide mapping on chromosome 3q13 identifies the kalirin gene as a novel candidate gene for coronary artery disease.American journal of human genetics · 2007Article
- The UNC-73/Trio RhoGEF-2 domain is required in separate isoforms for the regulation of pharynx pumping and normal neurotransmission in C. elegans.Genes & development · 2005Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Kalirin is a multidomain guanine nucleotide exchange factor for small GTPbinding proteins of the Rho family. It is expressed in multiple isoforms that contain different combinations of functional domains and display a complex pattern of expression during brain development. In addition to the isoforms generated through alternative splicing, we have identified multiple transcriptional start sites in rats and humans. These multiple transcriptional start sites result in full-length Kalirin transcripts possessing different 5' ends encoding proteins with differing amino termini. These alternative first exons display different patterns of expression in developing rats and humans and in cultured cells. Most of these alternate first exons lie >100 kb upstream of exon 2 in both rats and humans. Comparisons of the rat and human Kalirin promoter regions reveal numerous shared potential regulatory elements.
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