ArticleThe Plant cell2004
Two classes of the CDh1-type activators of the anaphase-promoting complex in plants: novel functional domains and distinct regulation.
Article in The Plant cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 83 citations in OpenAlex.
- A CDC20 allelic series reveals stage-specific control of metaphase-to-anaphase transitions during mitosis and meiosis in rice.Science China. Life sciences · 2026Article
- SUPPRESOR OF GAMMA RESPONSE 1 promotes early onset of endoreplication upon DNA double-strand breaks by inducing CCS52A1 expression in Arabidopsis roots.Journal of plant research · 2025Article
- ANAPHASE-PROMOTING COMPLEX/CYCLOSOME coactivators maintain AURORA 1 kinase homeostasis during meiotic chromosome segregation.The Plant cell · 2025Article
- Plant lineage-specific PIKMIN1 drives APC/CCCS52A2 E3-ligase activity-dependent cell division.Plant physiology · 2023Article
- SAMBA controls cell division rate during maize development.Plant physiology · 2022Article
- The role of APC/C in cell cycle dynamics, growth and development in cereal crops.Frontiers in plant science · 2022Review
- The Role of Anaphase-Promoting Complex/Cyclosome (APC/C) in Plant Reproduction.Frontiers in plant science · 2021Review
- Divide and Be Conquered-Cell Cycle Reactivation in Arbuscular Mycorrhizal Symbiosis.Frontiers in plant science · 2021Article
- The Cyclin CYCA3;4 Is a Postprophase Target of the APC/CThe Plant cell · 2020Article
- CCS52 and DEL1 function in root-knot nematode giant cell development in Xinjiang wild myrobalan plum (Prunus sogdiana Vassilcz).Protoplasma · 2020Article
- Cell Cycle Control by Nuclear Sequestration of CDC20 and CDH1 mRNA in Plant Stem Cells.Molecular cell · 2017Article
- Genome diversity of tuber-bearingProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Endocycles: a recurrent evolutionary innovation for post-mitotic cell growth.Nature reviews. Molecular cell biology · 2014Review
- Composition, roles, and regulation of cullin-based ubiquitin e3 ligases.The arabidopsis book · 2014Article
- Leaf development: a cellular perspective.Frontiers in plant science · 2014Review
- An insight into critical endocycle genes for plant-parasitic nematode feeding sites establishment.Plant signaling & behavior · 2013Article
- CCS52A2/FZR1, a cell cycle regulator, is an essential factor for shoot apical meristem maintenance in Arabidopsis thaliana.BMC plant biology · 2012Article
- Rice APC/C(TE) controls tillering by mediating the degradation of MONOCULM 1.Nature communications · 2012Article
- Article
- Conserved CDC20 cell cycle functions are carried out by two of the five isoforms in Arabidopsis thaliana.PloS one · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Cdc20 and Cdh1/Fzr proteins are the substrate-specific activators of the anaphase-promoting complex (APC). In Medicago truncatula, the MtCcs52A and MtCcs52B proteins represent two subgroups of the Cdh1-type activators, which display differences in their cell cycle regulation, structure, and function. The ccs52A transcripts are present in all phases of the cell cycle. By contrast, expression of ccs52B is restricted to late G2-phase and M-phase, and its induced overexpression in BY2 cells inhibited mitosis. MtCcs52A is active in Schizosaccharomyces pombe and binds to the S. pombe APC, whereas MtCcs52B does not because of differences in the N-terminal region. We identified a new functional domain, the Cdh1-specific motif conserved in the Cdh1 proteins that, in addition to the C-box and the terminal Ile and Arg residues, was essential for the activity and required for efficient binding to the APC. Moreover, we demonstrate that cyclin-dependent kinase phosphorylation sites adjacent to the C-box may regulate the interaction with the APC. In the different plant organs, the expression of Mtccs52A and Mtccs52B displayed differences and indicated the involvement of the APC in differentiation processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.