ArticleThe Journal of physiology2004
Congenital hypoventilation and impaired hypoxic response in Nurr1 mutant mice.
Article in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 59 citations in OpenAlex.
- Role of substantia Nigra dopaminergic neurons in respiratory modulation and limitations of levodopa in Parkinson's disease.Experimental neurology · 2025Article
- The association of gene polymorphisms of adenosine and dopamine receptors with the response to caffeine citrate treatment in infants with apnea of prematurity: a prospective nested case-control study.Italian journal of pediatrics · 2024Article
- L-DOPA Improves Ventilation but Not the Ventilatory Response to Hypercapnia in a Reserpine Model of Parkinson's Disease.Brain sciences · 2023Article
- Transgenic rodents as dynamic models for the study of respiratory rhythm generation and modulation: a scoping review and a bibliometric analysis.Frontiers in physiology · 2023Article
- Effects of Prenatal Cannabinoids Exposure upon Placenta and Development of Respiratory Neural Circuits.Advances in experimental medicine and biology · 2023Review
- Mortality and ventilatory effects of central serotonin deficiency during postnatal development depend on age but not sex.Physiological reports · 2021Article
- Article
- Central and peripheral chemoreceptors in sudden infant death syndrome.The Journal of physiology · 2018Review
- Modification and Application of a Commercial Whole-body Plethysmograph to Monitor Respiratory Abnormalities in Neonatal Mice.Bio-protocol · 2017Article
- Deficiency of CPEB2-Confined Choline Acetyltransferase Expression in the Dorsal Motor Nucleus of Vagus Causes Hyperactivated Parasympathetic Signaling-Associated Bronchoconstriction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Understanding the rhythm of breathing: so near, yet so far.Annual review of physiology · 2013Review
- Carotid chemoreceptor development in mice.Respiratory physiology & neurobiology · 2013Review
- Nurr1 regulates Top IIβ and functions in axon genesis of mesencephalic dopaminergic neurons.Molecular neurodegeneration · 2012Article
- The orphan nuclear receptor Nurr1 restricts the proliferation of haematopoietic stem cells.Nature cell biology · 2010Article
- D1/D2-dopamine receptor agonist dihydrexidine stimulates inspiratory motor output and depresses medullary expiratory neurons.American journal of physiology. Regulatory, integrative and comparative physiology · 2009Article
- Opioidergic and dopaminergic modulation of respiration.Respiratory physiology & neurobiology · 2008Review
- Running is rewarding and antidepressive.Physiology & behavior · 2007Review
- The NR4A subgroup: immediate early response genes with pleiotropic physiological roles.Nuclear receptor signaling · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nurr1, a transcription factor belonging to the family of nuclear receptors, is expressed at high levels immediately after birth. Gene-targeted mice lacking Nurr1 fail to develop midbrain dopaminergic neurones and do not survive beyond 24 h after birth. Dopamine (DA) levels may be regulated by Nurr1, and as DA is involved in both central and peripheral respiratory control, we hypothesized that lack of Nurr1 may impair breathing and cause death by respiratory failure. We demonstrate herein that Nurr1 newborn knockout mice have a severely disturbed breathing pattern characterized by hypoventilation, numerous apnoeas and failure to increase breathing when challenged with hypoxia. In heterozygote Nurr1 mice the response to hypoxia is also altered. Furthermore, the central respiratory rhythm, generated from isolated brainstem-spinal cord preparations, exhibits impaired response to hypoxia in mice lacking Nurr1. Moreover, Nurr1 is expressed in several respiratory-related regions of the nervous system, including the nucleus of the solitary tract, the nucleus ambiguus and the dorsal motor nucleus of the vagus nerve, and in the carotid bodies. The prominent Nurr1 expression in these areas, involved in respiratory control, along with the severe respiratory phenotype, indicates that Nurr1 plays a major role in the extrauterine adaption of respiratory control and the response to hypoxia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.