ArticleMolecular biology of the cell2004
NO66, a highly conserved dual location protein in the nucleolus and in a special type of synchronously replicating chromatin.
Article in Molecular biology of the cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 55 citations in OpenAlex.
- To Erase or Not to Erase: Non-Canonical Catalytic Functions and Non-Catalytic Functions of Members of Histone Lysine Demethylase Families.International journal of molecular sciences · 2024Review
- Exploring links between 2-oxoglutarate-dependent oxygenases and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Review
- Mechanisms Regulating Muscle Protein Synthesis in CKD.Journal of the American Society of Nephrology : JASN · 2020Article
- The small members of the JMJD protein family: Enzymatic jewels or jinxes?Biochimica et biophysica acta. Reviews on cancer · 2019Review
- Genome-Wide Association Study Identifies Genomic Loci Affecting Filet Firmness and Protein Content in Rainbow Trout.Frontiers in genetics · 2019Article
- The emerging roles of ribosomal histidyl hydroxylases in cell biology, physiology and disease.Cellular and molecular life sciences : CMLS · 2018Review
- Identification of pathways significantly associated with spondyloarthropathy/ankylosing spondylitis using the sub‑pathway method.Molecular medicine reports · 2018Article
- Phylogenetic and genomic analyses of the ribosomal oxygenases Riox1 (No66) and Riox2 (Mina53) provide new insights into their evolution.BMC evolutionary biology · 2018Article
- Systematic discovery of genetic modulation by Jumonji histone demethylases in Drosophila.Scientific reports · 2017Article
- Dysfunction of IKZF1/MYC/MDIG axis contributes to liver cancer progression through regulating H3K9me3/p21 activity.Cell death & disease · 2017Article
- Mesenchymal Deletion of Histone Demethylase NO66 in Mice Promotes Bone Formation.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015Article
- Structure of the JmjC domain-containing protein NO66 complexed with ribosomal protein Rpl8.Acta crystallographica. Section D, Biological crystallography · 2015Article
- Current understanding of mdig/MINA in human cancers.Genes & cancer · 2015Review
- Mesenchyme-specific overexpression of nucleolar protein 66 in mice inhibits skeletal growth and bone formation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Expression of histone methyltransferases as novel biomarkers for renal cell tumor diagnosis and prognostication.Epigenetics · 2015Article
- Mina: a Th2 response regulator meets TGFβ.Current opinion in immunology · 2014Review
- Ribosome biogenesis in skeletal development and the pathogenesis of skeletal disorders.Biochimica et biophysica acta · 2014Review
- Osterix and NO66 histone demethylase control the chromatin of Osterix target genes during osteoblast differentiation.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2014Article
- The roles of Jumonji-type oxygenases in human disease.Epigenomics · 2014Review
- Structural insights into histone demethylase NO66 in interaction with osteoblast-specific transcription factor osterix and gene repression.The Journal of biological chemistry · 2013Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has recently become clear that the nucleolus, the most prominent nuclear subcompartment, harbors diverse functions beyond its classic role in ribosome biogenesis. To gain insight into nucleolar functions, we have purified amplified nucleoli from Xenopus laevis oocytes using a novel approach involving fluorescence-activated cell sorting techniques. The resulting protein fraction was analyzed by mass spectrometry and used for the generation of monoclonal antibodies directed against nucleolar components. Here, we report the identification and molecular characterization of a novel, ubiquitous protein, which in most cell types appears to be a constitutive nucleolar component. Immunolocalization studies have revealed that this protein, termed NO66, is highly conserved during evolution and shows in most cells analyzed a dual localization pattern, i.e., a strong enrichment in the granular part of nucleoli and in distinct nucleoplasmic entities. Colocalizations with proteins Ki-67, HP1alpha, and PCNA, respectively, have further shown that the staining pattern of NO66 overlaps with certain clusters of late replicating chromatin. Biochemical experiments have revealed that protein NO66 cofractionates with large preribosomal particles but is absent from cytoplasmic ribosomes. We propose that in addition to its role in ribosome biogenesis protein NO66 has functions in the replication or remodeling of certain heterochromatic regions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.