ArticleMolecular biology of the cell2004
Mutant telomere sequences lead to impaired chromosome separation and a unique checkpoint response.
Article in Molecular biology of the cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- The adaptive molecular landscape of reprogrammed telomeric sequences.Nature communications · 2026Article
- A persistent variant telomere sequence in a human pedigree.Nature communications · 2024Article
- Pot1b -/- tumors activate G-quadruplex-induced DNA damage to promote telomere hyper-elongation.Nucleic acids research · 2023Article
- Investigating the role of G-quadruplexes atMicrobial cell (Graz, Austria) · 2022Article
- Retinoblastoma protein regulates carcinogen susceptibility at heterochromatic cancer driver loci.Life science alliance · 2022Article
- Article
- Mutations in the TERC template sequence can be incorporated into the telomeres of human tumors.PloS one · 2022Article
- Current Perspectives of Telomerase Structure and Function in Eukaryotes with Emerging Views on Telomerase in Human Parasites.International journal of molecular sciences · 2018Review
- Telomere dynamics in a lizard with morph-specific reproductive investment and self-maintenance.Ecology and evolution · 2017Article
- Review
- Genome-wide studies of telomere biology in budding yeast.Microbial cell (Graz, Austria) · 2014Review
- Saccharomyces cerevisiae as a Model to Study Replicative Senescence Triggered by Telomere Shortening.Frontiers in oncology · 2013Article
- Herpesvirus telomerase RNA (vTR) with a mutated template sequence abrogates herpesvirus-induced lymphomagenesis.PLoS pathogens · 2011Article
- Telomerase: an RNP enzyme synthesizes DNA.Cold Spring Harbor perspectives in biology · 2011Review
- Rudimentary G-quadruplex-based telomere capping in Saccharomyces cerevisiae.Nature structural & molecular biology · 2011Article
- Reprogramming murine telomerase rapidly inhibits the growth of mouse cancer cells in vitro and in vivo.Molecular cancer therapeutics · 2010Article
- ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells.Cancer research · 2008Article
- Telomerase repeat addition processivity is increased at critically short telomeres in a Tel1-dependent manner in Saccharomyces cerevisiae.Genes & development · 2007Article
- Regulation of telomere structure and functions by subunits of the INO80 chromatin remodeling complex.Molecular and cellular biology · 2007Article
- Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mutation of the template region in the RNA component of telomerase can cause incorporation of mutant DNA sequences at telomeres. We made all 63 mutant sequence combinations at template positions 474-476 of the yeast telomerase RNA, TLC1. Mutants contained faithfully incorporated template mutations, as well as misincorporated sequences in telomeres, a phenotype not previously reported for Saccharomyces cerevisiae telomerase template mutants. Although growth rates and telomere profiles varied widely among the tlc1 mutants, chromosome separation and segregation were always aberrant. The mutants showed defects in sister chromatid separation at centromeres as well as telomeres, suggesting activation of a cell cycle checkpoint. Deletion of the DNA damage response genes DDC1, MEC3, or DDC2/SML1 failed to restore chromosome separation in the tlc1 template mutants. These results suggest that mutant telomere sequences elicit a checkpoint that is genetically distinct from those activated by deletion of telomerase or DNA damage.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.