ArticleInfection and immunity2004
An msbB homologue carried in plasmid pO157 encodes an acyltransferase involved in lipid A biosynthesis in Escherichia coli O157:H7.
Article in Infection and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Identification and Characterization of Two Klebsiella pneumoniaeInfection and immunity · 2017Article
- Species-specific activation of TLR4 by hypoacylated endotoxins governed by residues 82 and 122 of MD-2.PloS one · 2014Article
- Protection from hemolytic uremic syndrome by eyedrop vaccination with modified enterohemorrhagic E. coli outer membrane vesicles.PloS one · 2014Article
- Recognition of lipid A variants by the TLR4-MD-2 receptor complex.Frontiers in cellular and infection microbiology · 2013Review
- Phylogenetic grouping and virulence potential of extended-spectrum-β-lactamase-producing Escherichia coli strains in cattle.Applied and environmental microbiology · 2012Article
- CTX-M-15 extended-spectrum β-lactamase in a shiga toxin-producing Escherichia coli isolate of serotype O111:H8.Applied and environmental microbiology · 2012Article
- Article
- Characterization of BNT2, an intrinsically curved DNA of Escherichia coli O157:H7.Biochemical and biophysical research communications · 2010Article
- Virulence, inflammatory potential, and adaptive immunity induced by Shigella flexneri msbB mutants.Infection and immunity · 2010Article
- A brief overview of Escherichia coli O157:H7 and its plasmid O157.Journal of microbiology and biotechnology · 2010Review
- Structural modifications of outer membrane vesicles to refine them as vaccine delivery vehicles.Biochimica et biophysica acta · 2009Article
- All blood, no stool: enterohemorrhagic Escherichia coli O157:H7 infection.Journal of veterinary science · 2008Review
- Differential regulation by magnesium of the two MsbB paralogs of Shigella flexneri.Journal of bacteriology · 2008Article
- PagP activation in the outer membrane triggers R3 core oligosaccharide truncation in the cytoplasm of Escherichia coli O157:H7.The Journal of biological chemistry · 2008Article
- Lipid A modification systems in gram-negative bacteria.Annual review of biochemistry · 2007Review
- The pCoo plasmid of enterotoxigenic Escherichia coli is a mosaic cointegrate.Journal of bacteriology · 2005Article
- Use of in vivo-induced antigen technology for identification of Escherichia coli O157:H7 proteins expressed during human infection.Infection and immunity · 2005Article
- Involvement of the Escherichia coli O157:H7(pO157) ecf operon and lipid A myristoyl transferase activity in bacterial survival in the bovine gastrointestinal tract and bacterial persistence in farm water troughs.Infection and immunity · 2005Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Escherichia coli O157:H7 carries a chromosomal msbB1 and a plasmid-encoded msbB2 gene. We characterized msbB2 function as a homologue of msbB1 by examination of wild-type organisms and mutant strains that lacked functional msbB1, msbB2, and both msbB1 and msbB2. The msbB double-mutant strain generated pentaacyl lipid A, while the single-mutant strains synthesized hexaacyl lipid A. Complementation with overexpressed msbB2 converted pentaacyl into hexaacyl lipid A in the double-mutant strain. The transcription of both msbB genes occurred simultaneously. Lack of MsbB2 activity slightly increased the microheterogeneity of the lipid A species. These results suggest that the msbB2 gene plays a role not only in the routine generation of fully hexaacylated lipid A but also in suppressing the microheterogeneity of lipid A species, the endotoxic determinant of the organism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.