ArticleInfection and immunity2004
Porphyromonas gingivalis genes involved in fimA regulation.
Article in Infection and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- OxyR activation in Porphyromonas gingivalis in response to a hemin-limited environment.Infection and immunity · 2012Article
- CsrA-FliW interaction governs flagellin homeostasis and a checkpoint on flagellar morphogenesis in Bacillus subtilis.Molecular microbiology · 2011Article
- Role of arginine deiminase of Streptococcus cristatus in Porphyromonas gingivalis colonization.Antimicrobial agents and chemotherapy · 2010Article
- Subgingival biofilm formation.Periodontology 2000 · 2010Review
- Negative correlation of distributions of Streptococcus cristatus and Porphyromonas gingivalis in subgingival plaque.Journal of clinical microbiology · 2009Article
- Identification of a signalling molecule involved in bacterial intergeneric communication.Microbiology (Reading, England) · 2007Article
- Porphyromonas gingivalis short fimbriae are regulated by a FimS/FimR two-component system.FEMS microbiology letters · 2007Article
- Posttranscriptional control of the Salmonella enterica flagellar hook protein FlgE.Journal of bacteriology · 2006Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Porphyromonas gingivalis is an important component of the complex plaque biofilm that is a direct precursor of periodontal disease. The major fimbriae are required for attachment to oral surfaces and are an important virulence factor. Fimbrillin (FimA) expression in P. gingivalis is inhibited by surface molecule of Streptococcus cristatus, an early colonizer of dental plaque. In this study, differential display PCR was used to identify P. gingivalis genes that are regulated in response to S. cristatus. Of several differentially expressed genes, pg2131 and pg2167 were upregulated by S. cristatus signaling molecules. A null mutant of pg2167 did not transcriptionally regulate fimA following exposure to S. cristatus. In fact, fimA transcription was enhanced in the pg2167 mutant, suggesting that pg2167 may act to repress fimA expression. In contrast, a mutation in pg2131 did not affect transcription of fimA in the presence of S. cristatus. However, production of fimbrillin was significantly diminished in the pg2131 mutant, implicating involvement in posttranscriptional regulation in fimbriation. These data suggest that P. gingivalis fimbriation is controlled by more than one regulation mechanism, involving both transcriptional and posttranscriptional processes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.