ArticleThe American journal of pathology2004
Enhanced cytomegalovirus infection in atherosclerotic human blood vessels.
Article in The American journal of pathology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 54 citations in OpenAlex.
- Comprehensive transcriptomics and proteomics analysis of neointima formation in human saphenous vein: implications for bypass graft disease.American journal of physiology. Heart and circulatory physiology · 2026Article
- Article
- Functional characterization of human IL-8 in vascular stenosis using a novel humanized transgenic mouse model.Vascular pharmacology · 2024Article
- Human cytomegalovirus modulates mTORC1 to redirect mRNA translation within quiescently infected monocytes.Journal of virology · 2024Article
- The knowns and unknowns of cardiac autoimmunity in viral myocarditis.Reviews in medical virology · 2023Review
- Human Cytomegalovirus Glycoprotein-Initiated Signaling Mediates the Aberrant Activation of Akt.Journal of virology · 2020Article
- Ocular cytomegalovirus latency exacerbates the development of choroidal neovascularization.The Journal of pathology · 2020Article
- HCMV modulation of cellular PI3K/AKT/mTOR signaling: New opportunities for therapeutic intervention?Antiviral research · 2019Review
- Aberrant regulation of the Akt signaling network by human cytomegalovirus allows for targeting of infected monocytes.Antiviral research · 2018Article
- Infectious myocarditis: the role of the cardiac vasculature.Heart failure reviews · 2018Review
- Human Cytomegalovirus Induces an Atypical Activation of Akt To Stimulate the Survival of Short-Lived Monocytes.Journal of virology · 2016Article
- Infection and Stroke: an Update on Recent Progress.Current neurology and neuroscience reports · 2016Review
- Elevated levels of circulating DNA in cardiovascular disease patients: metagenomic profiling of microbiome in the circulation.PloS one · 2014Article
- Human cytomegalovirus induces a biphasic inflammatory response in primary endothelial cells.Journal of virology · 2013Article
- Retinal arteriolar occlusions due to cytomegalovirus retinitis in elderly patients without HIV.Journal of ophthalmic inflammation and infection · 2013Article
- Infectious serologies and autoantibodies in hepatitis C and autoimmune disease-associated mixed cryoglobulinemia.Clinical reviews in allergy & immunology · 2012Review
- Significant increase in 1-year posttransplant renal arterial index predicts graft loss.Clinical journal of the American Society of Nephrology : CJASN · 2010Article
- Cytomegalovirus infection causes an increase of arterial blood pressure.PLoS pathogens · 2009Article
- Long-term cytomegalovirus infection leads to significant changes in the composition of the CD8+ T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons.Journal of virology · 2005Article
- Synergistic inhibition of human cytomegalovirus replication by interferon-alpha/beta and interferon-gamma.Virology journal · 2005Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Human cytomegalovirus (CMV) is a possible co-factor in atherogenesis and vascular occlusion, but its ability to actively infect medium and large blood vessels is unclear. A vascular explant model was adapted to investigate CMV infection in human coronary artery, internal mammary artery (IMA), and saphenous vein (SV). Vascular explants were inoculated with CMV Towne or low-passage clinical isolate and examined in situ for CMV cytopathic effect and immediate-early and early antigens, as indicators of active infection. At 5 to 7 days after inoculation, we found that CMV Towne actively infected eight of eight different atherosclerotic blood vessel explants (coronary artery, n = 4; SV and IMA grafts, n = 4), whereas it only infected 2 of 14 nonatherosclerotic blood vessel explants (SV, n = 10; IMA, n = 4) (P = 0.001). The CMV clinical isolate actively infected none of six sets of nonatherosclerotic SV explants at 5 to 7 days after inoculation. The active CMV infections involved adventitial and, less frequently, intimal cells. A small subset of infected cells in atherosclerotic tissue expresses the endothelial cell marker CD31. Smooth muscle cells residing in both atherosclerotic and nonatherosclerotic blood vessels were free of active CMV infections even after all vascular tissue layers were exposed to the virus. In contrast, active CMV Towne infection was evident at 2 days after inoculation in smooth muscle cells and endothelial cells previously isolated from the SV tissues. We conclude that active CMV infection is enhanced in atherosclerotic blood vessels compared to atherosclerosis-free vascular equivalents, and this viral activity is restricted to subpopulations of intimal and adventitial cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.