ArticleAntimicrobial agents and chemotherapy2004
In vitro and in vivo activities of the novel azole antifungal agent r126638.
Article in Antimicrobial agents and chemotherapy, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 49 citations in OpenAlex.
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- Towards a Standardized Procedure for the Production of Infective Spores to Study the Pathogenesis of Dermatophytosis.Journal of fungi (Basel, Switzerland) · 2021Article
- Relevant Animal Models in Dermatophyte Research.Mycopathologia · 2017Review
- Antifungal Treatment for Pityriasis Versicolor.Journal of fungi (Basel, Switzerland) · 2015Review
- Resistance to antifungals that target CYP51.Journal of chemical biology · 2014Review
- Animal model of dermatophytosis.Journal of biomedicine & biotechnology · 2012Review
- Topical Treatment of Dermatophytic Lesion on Mice (Mus musculus) Model.Indian journal of microbiology · 2011Article
- In vitro profiling of pramiconazole and in vivo evaluation in Microsporum canis dermatitis and Candida albicans vaginitis laboratory models.Antimicrobial agents and chemotherapy · 2010Article
- Conazoles.Molecules (Basel, Switzerland) · 2010Review
- Effect of culture medium on the disk diffusion method for determining antifungal susceptibilities of dermatophytes.Antimicrobial agents and chemotherapy · 2006Article
- Evaluation of disk diffusion method for determining eberconazole susceptibility of dermatophytes and influence of culture medium.Antimicrobial agents and chemotherapy · 2005Article
- The novel azole R126638 is a selective inhibitor of ergosterol synthesis in Candida albicans, Trichophyton spp., and Microsporum canis.Antimicrobial agents and chemotherapy · 2004Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
R126638 is a new triazole agent with potent antifungal activity in vitro against various dermatophytes, Candida spp., and Malassezia spp. Its activity against Malassezia spp. in vitro was superior to that of ketoconazole, the agent currently used for the treatment of Malassezia-related infections. R126638 showed activity comparable to or lower than that of itraconazole against dermatophytes in vitro; however, in guinea pig models of dermatophyte infections, R126638 given orally consistently showed antifungal activity superior to that of itraconazole, with 50% effective doses (ED(50)s) three- to more than eightfold lower than those of itraconazole, depending on the time of initiation and the duration of treatment. The ED(50) of R126638 in a mouse dermatophytosis model was more than fivefold lower than that of itraconazole. These data indicate that if the effects of R126638 seen when it is used to treat animals can be extrapolated to humans, the novel compound would be expected to show effects at doses lower than those of existing drugs and, hence, present a lower risk for side effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.