Evidence map›Paper›PMID 14740343›Full record

ReviewWiener klinische Wochenschrift2003

Genetic factors in assisted reproduction.

Christian J Gruber, Markus Hengstschläger, Heinz Leipold, Isabel M Gruber, Kathrin Ferlitsch, Doris M Gruber, Johannes C Huber

Abstract readComparative StudyReview
PubMed Publisher
In one paragraph

Review in Wiener klinische Wochenschrift, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. [Does the IVF regulation modify our medical management?].Wiener klinische Wochenschrift · 2008
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Christian J GruberDivision of Gynaecologic Endocrinology and Reproductive Medicine, University of Vienna Medical School, Vienna, Austria. christian_gruber@chello.at
Markus Hengstschläger
Heinz Leipold
Isabel M Gruber
Kathrin Ferlitsch
Doris M Gruber
Johannes C Huber
Medical University of Vienna · ATUniversity of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is still unclear whether the procedures of assisted reproduction increase the risk of congenital malformations. Thus, it remains to be clarified whether an increased risk, if any, of congenital malformations in these children is caused by the procedure of assisted reproduction itself or by the underlying maternal and paternal background. From the genetic point of view, infertility patients seeking assisted reproduction have to be classified as a high-risk group. The prevalence of numerical chromosomal abnormalities is around 10% in these patients, compared with 0.85% in the general population. The prevalence of structural chromosomal abnormalities is around 0.1% in the general population and is increased up to 1% in patients seeking assisted reproduction. In addition, patients with microdeletions of the Y-chromosome or mutations in the cystic fibrosis transmembrane-conductance regulator gene are likely to be encountered at the fertility clinic. Therefore, genetic screening and counselling should be routinely offered to infertility patients. They also need to understand that parental factors can be transferred to offspring that would most likely not have been conceived by natural means.

Indexed as

Chromosome AberrationsGenetic CounselingGenetic TestingReproductive Techniques, AssistedAdultChromosome DeletionChromosomes, Human, YCongenital AbnormalitiesCystic Fibrosis Transmembrane Conductance RegulatorFemaleHumansInfant, NewbornInfertility, FemaleInfertility, MaleMaleMutationCFTR protein, humanCystic Fibrosis Transmembrane Conductance Regulator

Identifiers

PMID14740343
OpenAlexW89724455

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.