ArticleHuman genetics2004
Patterns of linkage disequilibrium in the MHC region on human chromosome 6p.
Article in Human genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
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- Immunological drivers and potential novel drug targets for major psychiatric, neurodevelopmental, and neurodegenerative conditions.Molecular psychiatry · 2025Article
- Allele co-segregation and haplotype diversity of MHC IIβ genes in the small-spotted catshark Scyliorhinus canicula.Immunogenetics · 2025Article
- HLA amino acid Mismatch-Based risk stratification of kidney allograft failure using a novel Machine learning algorithm.Journal of biomedical informatics · 2023Article
- Heterozygosity of the major histocompatibility complex predicts later self-reported pubertal maturation in men.Scientific reports · 2021Article
- TheInnate immunity · 2021Article
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- HLA Heterozygote Advantage against HIV-1 Is Driven by Quantitative and Qualitative Differences in HLA Allele-Specific Peptide Presentation.Molecular biology and evolution · 2020Article
- Exploring the genetic relationship between hearing impairment and Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- Gene Set Enrichment Analyses: lessons learned from the heart failure phenotype.BioData mining · 2017Article
- The influence of positive selection and trans-species evolution on DPB diversity in the golden snub-nosed monkeys (Rhinopithecus roxellana).Primates; journal of primatology · 2016Article
- Very long haplotype tracts characterized at high resolution from HLA homozygous cell lines.Immunogenetics · 2015Article
- Genome-wide association study of behavioural and psychiatric features in human prion disease.Translational psychiatry · 2015Article
- The major histocompatibility complex: a model for understanding graft-versus-host disease.Blood · 2013Review
- Identification of the NF-κB activating protein-like locus as a risk locus for rheumatoid arthritis.Annals of the rheumatic diseases · 2013Article
- Testing for drug hypersensitivity syndromes.The Clinical biochemist. Reviews · 2013Article
- Functional gene polymorphism to reveal species history: the case of the CRTISO gene in cultivated carrots.PloS one · 2013Article
- Hypothesis-driven candidate genes for schizophrenia compared to genome-wide association results.Psychological medicine · 2012Article
- New genetic associations detected in a host response study to hepatitis B vaccine.Genes and immunity · 2010Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Single nucleotide polymorphisms (SNPs) in the human genome are thought to be organised into blocks of high internal linkage disequilibrium (LD), separated by intermittent recombination hotspots. Since understanding haplotype structure is critical for an accurate assessment of inter-individual genetic differences, we investigated up to 968 SNPs from a 10-Mb region on chromosome 6p21, including the human major histocompatibility complex (MHC), in five different population samples (45-550 individuals). Regions of well-defined block structure were found to coexist alongside large areas lacking any clear structure; occasional long-range LD was observed in all five samples. The four white populations analysed were remarkably similar in terms of the extend and spatial distribution of local LD. In US African Americans, the distribution of LD was similar to that in the white populations but the observed haplotype diversity was higher. The existence of large regions without any clear block structure renders the systematic and thorough construction of SNP haplotype maps a crucial prerequisite for disease-association studies.
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