ArticleDiabetologia2004
Long-chain CoA esters activate human pancreatic beta-cell KATP channels: potential role in Type 2 diabetes.
Article in Diabetologia, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Contribution of Mitochondria to Insulin Secretion by Various Secretagogues.Antioxidants & redox signaling · 2022Review
- Diet-Induced Metabolic Dysfunction of Hypothalamic Nutrient Sensing in Rodents.International journal of molecular sciences · 2022Review
- What Is the Metabolic Amplification of Insulin Secretion and Is It (Still) Relevant?Metabolites · 2021Review
- Lipotoxic Impairment of Mitochondrial Function in β-Cells: A Review.Antioxidants (Basel, Switzerland) · 2021Review
- The Pancreatic β-Cell: The Perfect Redox System.Antioxidants (Basel, Switzerland) · 2021Review
- Insulin Release Mechanism Modulated by Toxins Isolated from Animal Venoms: From Basic Research to Drug Development Prospects.Molecules (Basel, Switzerland) · 2019Review
- Inhibition of cholinergic potentiation of insulin secretion from pancreatic islets by chronic elevation of glucose and fatty acids: Protection by casein kinase 2 inhibitor.Molecular metabolism · 2017Article
- The Role of Circulating Amino Acids in the Hypothalamic Regulation of Liver Glucose Metabolism.Advances in nutrition (Bethesda, Md.) · 2016Review
- Fatty Acid Regulation of Voltage- and Ligand-Gated Ion Channel Function.Frontiers in physiology · 2016Review
- Metabolomics applied to the pancreatic islet.Archives of biochemistry and biophysics · 2016Review
- Increased glucose metabolism and glycerolipid formation by fatty acids and GPR40 receptor signaling underlies the fatty acid potentiation of insulin secretion.The Journal of biological chemistry · 2014Article
- Intracellular long-chain acyl CoAs activate TRPV1 channels.PloS one · 2014Article
- Activation of GPR40 as a therapeutic target for the treatment of type 2 diabetes.Diabetes care · 2013Review
- Reinterpreting the action of ATP analogs on K(ATP) channels.The Journal of biological chemistry · 2013Article
- Metabolome response to glucose in the β-cell line INS-1 832/13.The Journal of biological chemistry · 2013Article
- Reactive oxygen species stimulate insulin secretion in rat pancreatic islets: studies using mono-oleoyl-glycerol.PloS one · 2012Article
- A dual action of saturated fatty acids on electrical activity in rat pancreatic β-cells. Role of volume-regulated anion channel and KATP channel currents.The Journal of physiology · 2011Article
- Electrical short-circuit in β-cells from a patient with non-insulinoma pancreatogenous hypoglycemic syndrome (NIPHS): a case report.Journal of medical case reports · 2010Article
- Self-association of transmembrane domain 2 (TM2), but not TM1, in carnitine palmitoyltransferase 1A: role of GXXXG(A) motifs.The Journal of biological chemistry · 2009Article
- Nitro-fatty acid metabolome: saturation, desaturation, beta-oxidation, and protein adduction.The Journal of biological chemistry · 2009Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
aims/hypothesisThe ATP-regulated potassium (KATP) channel in the pancreatic beta cell couples the metabolic state to electrical activity. The primary regulator of the KATP channel is generally accepted to be changes in ATP/ADP ratio, where ATP inhibits and ADP activates channel activity. Recently, we showed that long-chain CoA (LC-CoA) esters form a new class of potent KATP channel activators in rodents, as studied in inside-out patches.
methodsIn this study we have investigated the effects of LC-CoA esters in human pancreatic beta cells using the inside-out and whole-cell configurations of the patch clamp technique.
resultsHuman KATP channels were potently activated by acyl-CoA esters with a chain length exceeding 12 carbons. Activation by LC-CoA esters did not require the presence of Mg2+ or adenine nucleotides. A detailed characterization of the concentration-dependent relationship showed an EC50 of 0.7+/-0.1 micromol/l. Furthermore, in the presence of an ATP/ADP ratio of 10 (1.1 mmol/l total adenine nucleotides), whole-cell KATP channel currents increased approximately six-fold following addition of 1 micro mol/l LC-CoA ester. The presence of 1 micro mol/l LC-CoA in the recording pipette solution increased beta-cell input conductance, from 0.5+/-0.2 nS to 2.5+/-1.3 nS. CONCLUSION/
interpretationTaken together, these results show that LC-CoA esters are potent activators of the KATP channel in human pancreatic beta cells. The fact that LC-CoA esters also stimulate KATP channel activity recorded in the whole-cell configuration, points to the ability of these compounds to have an important modulatory role of human beta-cell electrical activity under both physiological and pathophysiological conditions.
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Registered trials
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