ArticleThe EMBO journal2004
Phosphorylation of MRF4 transactivation domain by p38 mediates repression of specific myogenic genes.
Article in The EMBO journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 65 citations in OpenAlex.
- Semaphorins: Missing Signals in Age-dependent Alteration of Neuromuscular Junctions and Skeletal Muscle Regeneration.Aging and disease · 2024Review
- Out of Control: The Role of the Ubiquitin Proteasome System in Skeletal Muscle during Inflammation.Biomolecules · 2021Review
- Transcription factor signal transducer and activator of transcription 6 (STAT6) is an inhibitory factor for adult myogenesis.Skeletal muscle · 2021Article
- Nuclear P38: Roles in Physiological and Pathological Processes and Regulation of Nuclear Translocation.International journal of molecular sciences · 2020Review
- Genetic deletion of microRNA biogenesis in muscle cells reveals a hierarchical non-clustered network that controls focal adhesion signaling during muscle regeneration.Molecular metabolism · 2020Article
- Inflammation and Skeletal Muscle Wasting During Cachexia.Frontiers in physiology · 2020Review
- p38 and Casein Kinase 2 Mediate Ribonuclease 1 Repression in Inflamed Human Endothelial Cells via Promoter Remodeling Through Nucleosome Remodeling and Deacetylase Complex.Frontiers in cell and developmental biology · 2020Article
- An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling.F1000Research · 2020Review
- Akirin1 promotes myoblast differentiation by modulating multiple myoblast differentiation factors.Bioscience reports · 2019Article
- The myogenic regulatory factors, determinants of muscle development, cell identity and regeneration.Seminars in cell & developmental biology · 2017Review
- Praja1 E3 ubiquitin ligase promotes skeletal myogenesis through degradation of EZH2 upon p38α activation.Nature communications · 2017Article
- The role of sex steroid hormones in the pathophysiology and treatment of sarcopenia.Osteoporosis and sarcopenia · 2016Review
- The anabolic catabolic transforming agent (ACTA) espindolol increases muscle mass and decreases fat mass in old rats.Journal of cachexia, sarcopenia and muscle · 2014Article
- Identification of Map4k4 as a novel suppressor of skeletal muscle differentiation.Molecular and cellular biology · 2013Article
- TAK-1/p38/nNFκB signaling inhibits myoblast differentiation by increasing levels of Activin A.Skeletal muscle · 2012Article
- Proline isomerase Pin1 represses terminal differentiation and myocyte enhancer factor 2C function in skeletal muscle cells.The Journal of biological chemistry · 2010Article
- Regulatory interactions between muscle and the immune system during muscle regeneration.American journal of physiology. Regulatory, integrative and comparative physiology · 2010Review
- Emerging parallels between stomatal and muscle cell lineages.Plant physiology · 2009Article
- TNF-alpha regulates myogenesis and muscle regeneration by activating p38 MAPK.American journal of physiology. Cell physiology · 2007Article
- TACE release of TNF-alpha mediates mechanotransduction-induced activation of p38 MAPK and myogenesis.Journal of cell science · 2007Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skeletal myogenesis is associated with the activation of four muscle regulatory factors (MRFs): Myf5, MyoD, Myogenin and MRF4. Here we report that p38 mitogen-activated protein kinase represses the transcriptional activity of MRF4 (involved in late stages of myogenesis), resulting in downregulation of specific muscle genes. MRF4 is phosphorylated in vitro and in vivo by p38 on two serines (Ser31 and Ser42) located in the N-terminal transactivation domain, resulting in reduced MRF4-mediated transcriptional activity. In contrast, nonphosphorylatable MRF4 mutants display increased transcriptional activity and are able to advance both myoblast fusion and differentiation. We also show that expression of desmin and alpha-actin, but not muscle creatin kinase, decreased at late stages of muscle differentiation, correlating with the induction of MRF4 and p38 activation. Accordingly, inhibition of p38 during late myogenesis results in the upregulation of both desmin and alpha-actin. We propose that repression of MRF4 activity by p38 phosphorylation may represent a new mechanism for the silencing of specific muscle genes at the terminal stages of muscle differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.