ArticleVirus genes2004
Evidence of chromosomal integration of AAV DNA in human testis tissue.
Article in Virus genes, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 26 citations in OpenAlex.
- Adeno-associated virus infection and its impact in human health: an overview.Virology journal · 2022Review
- Steerable Induction of the Thymosin β4/MRTF-A Pathway via AAV-Based Overexpression Induces Therapeutic Neovascularization.Human gene therapy · 2017Article
- AAV: An Overview of Unanswered Questions.Human gene therapy · 2017Review
- Safe harbours for the integration of new DNA in the human genome.Nature reviews. Cancer · 2011Review
- Non-retroviral fossils in vertebrate genomes.Viruses · 2011Review
- Adeno-associated virus vector integration.Current opinion in molecular therapeutics · 2009Review
- Reducing the risk of adeno-associated virus (AAV) vector mobilization with AAV type 5 vectors.Journal of virology · 2009Article
- Infectious molecular clones of adeno-associated virus isolated directly from human tissues.Journal of virology · 2009Article
- Preferential integration of adeno-associated virus type 2 into a polypyrimidine/polypurine-rich region within AAVS1.Journal of virology · 2007Article
- Detection of adeno-associated virus type 2 genome in cervical carcinoma.British journal of cancer · 2006Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Persistent infection with adeno-associated virus (AAV) has been demonstrated in human tissues, most frequently in the female and male genital tract. The clinical significance of latent AAV infection remains, however, uncertain to date. The mode of latency of AAV is not known, i.e., it is unclear whether the viral genome is integrated in the cellular genome, and if integration occurs site-specifically in chromosome 19 as has been observed in cell culture. Therefore we investigated if viral DNA in AAV DNA-positive human testis samples from two patients, is integrated in the cellular genome. Using two different molecular approaches, uni-directional PCR and Walking Primer PCR, we could demonstrate that AAV DNA is present in an integrated form in testis tissue. Virus-cell DNA junction fragments were cloned and sequenced. A detailed analysis revealed integration within sequences of the so-called AAVS1 region on chromosome 19. These data demonstrate that AAV DNA can integrate also after natural infection, and that integration occurs within the AAVS1 region, at least in some cases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.