ArticleProtein science : a publication of the Protein Society2004
Phylogenetic and evolutionary analysis of the PLUNC gene family.
Article in Protein science : a publication of the Protein Society, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 84 citations in OpenAlex.
- The Acari Hypothesis, V: deciphering allergenicity.Frontiers in allergy · 2024Article
- BPIFB3 interacts with ARFGAP1 and TMED9 to regulate non-canonical autophagy and RNA virus infection.Journal of cell science · 2021Article
- LunX-CAR T Cells as a Targeted Therapy for Non-Small Cell Lung Cancer.Molecular therapy oncolytics · 2020Article
- BPIFB3 Regulates Endoplasmic Reticulum Morphology To Facilitate Flavivirus Replication.Journal of virology · 2020Article
- Human and Nonhuman Primate Lineage-Specific Footprints in the Salivary Proteome.Molecular biology and evolution · 2020Article
- Novel heterozygous BPIFC variant in a Chinese pedigree with hereditary trichilemmal cysts.Molecular genetics & genomic medicine · 2019Article
- Levels of horse allergen Equ c 4 in dander and saliva from ten horse breeds.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019Article
- Article
- An innate defense peptide BPIFA1/SPLUNC1 restricts influenza A virus infection.Mucosal immunology · 2018Article
- Arabidopsis LBP/BPI related-1 and -2 bind to LPS directly and regulate PR1 expression.Scientific reports · 2016Article
- Gammaherpesvirus infection modulates the temporal and spatial expression of SCGB1A1 (CCSP) and BPIFA1 (SPLUNC1) in the respiratory tract.Laboratory investigation; a journal of technical methods and pathology · 2015Article
- Domain similarity based orthology detection.BMC bioinformatics · 2015Article
- Bactericidal/Permeability-increasing protein fold-containing family member A1 in airway host protection and respiratory disease.American journal of respiratory cell and molecular biology · 2015Review
- The structure of latherin, a surfactant allergen protein from horse sweat and saliva.Journal of the Royal Society, Interface · 2013Article
- Short palate, lung, and nasal epithelial clone-1 is a tightly regulated airway sensor in innate and adaptive immunity.American journal of respiratory cell and molecular biology · 2013Article
- SPLUNC1/BPIFA1 contributes to pulmonary host defense against Klebsiella pneumoniae respiratory infection.The American journal of pathology · 2013Article
- Multifunctional role of human SPLUNC1 in Pseudomonas aeruginosa infection.Infection and immunity · 2013Article
- Differential localisation of BPIFA1 (SPLUNC1) and BPIFB1 (LPLUNC1) in the nasal and oral cavities of mice.Cell and tissue research · 2012Article
- BPIFB1 (LPLUNC1) is upregulated in cystic fibrosis lung disease.Histochemistry and cell biology · 2012Article
- LPLUNC1 modulates innate immune responses to Vibrio cholerae.The Journal of infectious diseases · 2011Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The PLUNC family of human proteins are candidate host defense proteins expressed in the upper airways. The family subdivides into short (SPLUNC) and long (LPLUNC) proteins, which contain domains predicted to be structurally similar to one or both of the domains of bactericidal/permeability-increasing protein (BPI), respectively. In this article we use analysis of the human, mouse, and rat genomes and other sequence data to examine the relationships between the PLUNC family proteins from humans and other species, and between these proteins and members of the BPI family. We show that PLUNC family clusters exist in the mouse and rat, with the most significant diversification in the locus occurring for the short PLUNC family proteins. Clear orthologous relationships are established for the majority of the proteins, and ambiguities are identified. Completion of the prediction of the LPLUNC4 proteins reveals that these proteins contain approximately a 150-residue insertion encoded by an additional exon. This insertion, which is predicted to be largely unstructured, replaces the structure homologous to the 40s hairpin of BPI. We show that the exon encoding this region is anomalously variable in size across the LPLUNC proteins, suggesting that this region is key to functional specificity. We further show that the mouse and human PLUNC family orthologs are evolving rapidly, which supports the hypothesis that these proteins are involved in host defense. Intriguingly, this rapid evolution between the human and mouse sequences is replaced by intense purifying selection in a large portion of the N-terminal domain of LPLUNC4. Our data provide a basis for future functional studies of this novel protein family.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.