ArticleBlood2004
Genetic variation responsible for mouse strain differences in integrin alpha 2 expression is associated with altered platelet responses to collagen.
Article in Blood, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 40 citations in OpenAlex.
- Pulmonary Thromboembolism Due to Intravenous Fibrocyte Administration in C57BL/6J Mice (Mus musculus) and Recommendations for Refinement.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- Differential susceptibility of mouse strains on pancreatic injury and regeneration in cerulein-induced pancreatitis.International journal of clinical and experimental pathology · 2017Article
- Effect of crossing C57BL/6 and FVB mouse strains on basal cytokine expression.Mediators of inflammation · 2015Article
- Epigenetic coordination of embryonic heart transcription by dynamically regulated long noncoding RNAs.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Genetic background, gender, age, body temperature, and arterial blood pH have a major impact on myocardial infarct size in the mouse and need to be carefully measured and/or taken into account: results of a comprehensive analysis of determinants of infarct size in 1,074 mice.Basic research in cardiology · 2012Article
- EMILIN2 (Elastin microfibril interface located protein), potential modifier of thrombosis.Thrombosis journal · 2011Article
- VAMP8/endobrevin is overexpressed in hyperreactive human platelets: suggested role for platelet microRNA.Journal of thrombosis and haemostasis : JTH · 2010Article
- Murine strain differences in hemostasis and thrombosis and tissue factor pathway inhibitor.Thrombosis research · 2010Article
- Distinct spatio-temporal Ca2+ signaling elicited by integrin alpha2beta1 and glycoprotein VI under flow.Blood · 2009Article
- Rap1b is critical for glycoprotein VI-mediated but not ADP receptor-mediated alpha2beta1 activation.Journal of thrombosis and haemostasis : JTH · 2009Article
- Induction of a VLA-2 (CD49b)-expressing effector T cell population by a cell-based neuroblastoma vaccine expressing CD137L.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Article
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- Dysfunctional platelet membrane receptors: from humans to mice.Thrombosis and haemostasis · 2004Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
As mouse models have become commonplace for studying hemostasis and thrombosis, we considered whether the mouse system had utility for assessing genetic alterations in platelet receptors. Platelets from 5 mouse strains (C57BL/6 [C57], FVB/N [FVB], BALB/c, C3H/He, and 129Sv) showed only minor differences in the expression of integrin alpha(IIb), integrin beta(3), glycoprotein (GP) Ib alpha, or GPVI across strains. However, FVB platelets expressed approximately 50% the level of integrin alpha(2) as platelets from other strains (P <.0001). We bred FVB mice with C57 and assessed alpha(2) expression in FVB/C57xFVB/C57 (F2) offspring. Linkage analysis demonstrated the gene responsible for alpha(2) levels is tightly linked to the D13mit260 marker (log odds [lod] score 6.7) near the alpha(2) gene. FVB platelets showed reduced aggregation and a longer lag phase to collagen. FVB and C57 platelets aggregated similarly to collagen-related peptide, but FVB platelets showed a reduction in rhodocytin-induced Syk and PLC gamma 2 tyrosine phosphorylation. Thus, FVB platelets express half the level of alpha(2) as other mouse strains, a trait linked to the alpha(2) gene and seemingly responsible for reduced platelet aggregation to collagen. These strain differences serve as a useful model for the 2-fold difference in human platelet alpha(2)beta(1) expression and demonstrate that alpha(2)beta(1) participates in signaling during platelet activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.