Evidence map›Paper›PMID 14738760›Full record

ReviewImmunity2004

Plasticity of T cell memory responses to viruses.

Liisa K Selin, Raymond M Welsh

Abstract readReview
In one paragraph

Review in Immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

  1. Article
  2. Article
  3. Revisiting the Principles of Designing a Vaccine.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Vaccination and heterologous immunity: educating the immune system.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2015
    Review
  12. Review
  13. Article
  14. Allospecific CD4(+) effector memory T cells do not induce graft-versus-host disease in mice.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2012
    Article
  15. Article
  16. Article
  17. Article
  18. The narrowing of the CD8 T cell repertoire in old age.Current opinion in immunology · 2011
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Liisa K SelinDepartment of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA.
Raymond M Welsh

Funding

Tetramer CoreP01AI049320 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LUZURIAGA, KATHERINE F · 2001 to 2016
$22.3M
Virology and Technology CoreP01AI046629 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GREINER, DALE LESLIE · 1999 to 2014
$19.1M
PILOT AND FEASIBILITY PROGRAMP30DK032520 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CZECH, MICHAEL P · 1986 to 2010
$14.6M
Immunity and Virus DiseaseR37AI017672 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI WELSH, RAYMOND M · 2004 to 2013
$4.0M
VIRUS-INDUCED IMMUNOPATHOLOGYR01AR035506 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI WELSH, RAYMOND M · 1986 to 2008
$3.3M
IMMUNITY IN SYSTEMIC AND MUCOSAL VIRUS INFECTIONSR01AI046578 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SELIN, LIISA KAARINA · 2000 to 2009
$3.1M
IMMUNITY AND VIRUS DISEASER01AI017672 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI WELSH, RAYMOND M · 1985 to 2003
$1.4M
NIAID NIH HHS AI17672NIAID NIH HHS AI46578NIAID NIH HHS AI46629NIAID NIH HHS AI49320NIAID NIH HHS P01 AI046629NIAID NIH HHS P01 AI049320NIAID NIH HHS R01 AI017672NIAID NIH HHS R01 AI046578NIAID NIH HHS R37 AI017672NIAMS NIH HHS AR35506NIAMS NIH HHS R01 AR035506NIDDK NIH HHS DK32520NIDDK NIH HHS P30 DK032520
6 · The paper itself

Abstract

Virus-specific memory T cell populations demonstrate plasticity in antigenic and functional phenotype, in recognition of antigen, and in their ability to accommodate new memory T cell populations. The adaptability of complex antigen-specific T cell repertoires allows the host to respond to a diverse array of pathogens and accommodate memory pools to many pathogens in a finite immune system. This is in part accounted for by crossreactive memory T cells, which can be employed in immune responses and mediate protective immunity or life-threatening immunopathology.

Indexed as

AnimalsCross ReactionsHumansImmunologic MemoryInfluenza A virusLymphocytic choriomeningitis virusMiceMuromegalovirusPhenotypeReceptors, Antigen, T-CellT-LymphocytesVirus DiseasesReceptors, Antigen, T-Cell

Identifiers

PMID14738760
PMCPMC7130098

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.