ArticleClinical and experimental immunology2004
Fluvastatin treatment inhibits leucocyte adhesion and extravasation in models of complement-mediated acute inflammation.
Article in Clinical and experimental immunology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Clinical review: Statins and trauma--a systematic review.Critical care (London, England) · 2013Pooled it
- Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers.American journal of respiratory and critical care medicine · 2009Trial
- Lipidomics in Understanding Pathophysiology and Pharmacologic Effects in Inflammatory Diseases: Considerations for Drug Development.Metabolites · 2022Review
- Fluvastatin Induces Apoptosis in Primary and Transformed Mast Cells.The Journal of pharmacology and experimental therapeutics · 2020Article
- Expression of SOX2, NANOG and OCT4 in a mouse model of lipopolysaccharide-induced acute uterine injury and intrauterine adhesions.Reproductive biology and endocrinology : RB&E · 2017Article
- Preoperative statin administration does not protect against early postoperative acute respiratory distress syndrome: a retrospective cohort study.Anesthesia and analgesia · 2014Observational
- Validity of SW982 synovial cell line for studying the drugs against rheumatoid arthritis in fluvastatin-induced apoptosis signaling model.The Indian journal of medical research · 2014Article
- Short term statin treatment improves survival and differentially regulates macrophage-mediated responses to Staphylococcus aureus.Current pharmaceutical biotechnology · 2013Article
- Statins in the critically ill.Annals of intensive care · 2012Article
- Year in review 2010: Critical Care--Respirology.Critical care (London, England) · 2011Review
- Novel lipid mediators promote resolution of acute inflammation: impact of aspirin and statins.Circulation research · 2010Review
- Acute lung injury and the acute respiratory distress syndrome in Ireland: a prospective audit of epidemiology and management.Critical care (London, England) · 2008Article
- Statins inhibit lymphocyte homing to peripheral lymph nodes.Immunology · 2007Article
- Fluvastatin reduced liver injury in rat model of extrahepatic cholestasis.Pediatric surgery international · 2007Article
- Simvastatin treatment ameliorates autoimmune disease associated with accelerated atherosclerosis in a murine lupus model.Journal of immunology (Baltimore, Md. : 1950) · 2006Article
- Statin-induced expression of CD59 on vascular endothelium in hypoxia: a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis.Arthritis research & therapy · 2006Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Complement activation plays a relevant role in the development of tissue damage under inflammatory conditions, and clinical and experimental observations emphasize its contribution to inflammatory vasculitides. Statins have recently been shown to reduce cardiovascular morbidity independently of plasma cholesterol lowering and in vitro studies support a direct anti-inflammatory action of these drugs. The aim of this study was to verify the in vivo effect of fluvastatin on complement-mediated acute peritoneal inflammation. The effect of oral treatment with fluvastatin was investigated in normo-cholesterolaemic rats that received intraperitoneal injection of either yeast-activated rat serum (Y-act RS) or lipopolysaccharide to induce peritoneal inflammation monitored by the number of PMN recruited in peritoneal fluid washes. In addition, vascular adherence and extravasation of leucocytes were evaluated by direct videomicroscopy examination on mesentery postcapillary venules topically exposed to Y-act RS. The number of PMN in the peritoneal washes of rats treated with fluvastatin was 38% lower than that of untreated animals (P < 0.05) 12 h after LPS injection, and was even lower (56%) in rats treated with Y-act RS already 8 h after injection (P < 0.02). Firm adhesion to endothelium and extravasation of leucocytes evaluated under direct videomicroscopy observation were significantly inhibited in fluvastatin treated rats (77% and 72%, respectively; P < 0.01), 120 min after treatment with Y-act RS. Our results demonstrate that fluvastatin inhibits in vivo complement-dependent acute peritoneal inflammation and suggest a role for statins in preventing the inflammatory flares usually associated with complement activation in chronic diseases, such as SLE or rheumatoid arthritis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.