ReviewOncogene2004
p53 protein variants: structural and functional similarities with p63 and p73 isoforms.
Review in Oncogene, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- A Novel Role of SMG1 in Cholesterol Homeostasis That Depends Partially on p53 Alternative Splicing.Cancers · 2022Article
- Review
- p53 Isoforms in Cellular Senescence- and Ageing-Associated Biological and Physiological Functions.International journal of molecular sciences · 2019Review
- Capn5 Expression in the Healthy and Regenerating Zebrafish Retina.Investigative ophthalmology & visual science · 2018Article
- Protein kinase D inhibitor CRT0066101 suppresses bladder cancer growth in vitro and xenografts via blockade of the cell cycle at G2/M.Cellular and molecular life sciences : CMLS · 2018Article
- Role of p63 and p73 isoforms on the cell death in patients with hepatocellular carcinoma submitted to orthotopic liver transplantation.PloS one · 2017Article
- Significant Prognostic Features and Patterns of SomaticCancer informatics · 2017Article
- Somatic TP53 Mutations in the Era of Genome Sequencing.Cold Spring Harbor perspectives in medicine · 2016Review
- Article
- The Role of the p53 Protein in Stem-Cell Biology and Epigenetic Regulation.Cold Spring Harbor perspectives in medicine · 2016Review
- Gene expression and splicing alterations analyzed by high throughput RNA sequencing of chronic lymphocytic leukemia specimens.BMC cancer · 2015Article
- Non-small cell lung cancer is susceptible to induction of DNA damage responses and inhibition of angiogenesis by telomere overhang oligonucleotides.Cancer letters · 2014Article
- Alterations of p63 and p73 in human cancers.Sub-cellular biochemistry · 2014Review
- Epstein - Barr virus transforming protein LMP-1 alters B cells gene expression by promoting accumulation of the oncoprotein ΔNp73α.PLoS pathogens · 2013Article
- Overexpression of p53 protein in human tumors.Medical molecular morphology · 2012Review
- TAp63γ demethylation regulates protein stability and cellular distribution during neural stem cell differentiation.PloS one · 2012Article
- Novel ARF/p53-independent senescence pathways in cancer repression.Journal of molecular medicine (Berlin, Germany) · 2011Review
- Tracing the protectors path from the germ line to the genome.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Tumor suppression by p53: making cells senescent.Histology and histopathology · 2010Review
- Regulation of p53 expression, phosphorylation and subcellular localization by a G-protein-coupled receptor.Oncogene · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since its discovery in 1979, many studies have reported that the p53 tumour suppressor protein could be expressed in the form of products smaller than those predicted by the full-length amino-acid sequence. These products differ from full-length p53 in their N- or C-terminal regions, but generally conserve the central, DNA-binding domain. They appear to be expressed at rather low levels and to be restricted to particular cell types and/or physiological circumstances, suggesting that they play very narrow and specific roles. Several mechanisms have been proposed to explain their timely occurrence, including alternative splicing, internal initiation of translation or proteolytic cleavage. A precise assessment of the various 'p53 isoforms' reveals striking similarities with several isoforms of the p53 homologous proteins p63 or p73, suggesting that regulated production of specific, N- or C-terminal variants may be a 'trademark' of all family members. In this review, we summarize the published evidence on the structure, mode of production, expression and function of the p53 isoforms, and discuss their properties in the light of recent data on the structure and function of p63/p73 isoforms.
Indexed as
Identifiers
14737098What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.