Trial reportArchives of disease in childhood2004
A randomised controlled trial of standing programme on bone mineral density in non-ambulant children with cerebral palsy.
Trial report in Archives of disease in childhood, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05113433 (Effects of Different Time Period of Standing Frame on Spasticity and Gait in Children With Spastic Cerebral Palsy.), which is not on this map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Different Time Period of Standing Frame on Spasticity and Gait in Children With Spastic Cerebral Palsy.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 160 citations in OpenAlex.
- WHOLE-BODY VIBRATION EXERCISE IS WELL TOLERATED IN PATIENTS WITH DUCHENNE MUSCULAR DYSTROPHY: A SYSTEMATIC REVIEW.African journal of traditional, complementary, and alternative medicines : AJTCAM · 2017Pooled it
- Clinical Guidelines for Management of Bone Health in Rett Syndrome Based on Expert Consensus and Available Evidence.PloS one · 2016Pooled it
- Trial
- Effects of whole-body vibration training on physical function, bone and muscle mass in adolescents and young adults with cerebral palsy.Scientific reports · 2016Trial
- Sliding and lower limb mechanics during sit-stand-sit transitions with a standing wheelchair.BioMed research international · 2014Trial
- Osteopenia in children with cerebral palsy can be treated with oral alendronate.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2012Trial
- Foot Weight-Bearing in Supported Standing: Influence of Verticalization Angles and Hip/Knee Flexion in Children and Adolescents with Cerebral Palsy (GMFCS IV-V).Children (Basel, Switzerland) · 2026Article
- Supported Standing and Supported Stepping Devices for Children with Non-Ambulant Cerebral Palsy: An Interdependence and F-Words Focus.International journal of environmental research and public health · 2024Article
- Epidemiology of fractures in children with cerebral palsy: a Swedish population-based registry study.BMC musculoskeletal disorders · 2022Article
- Description of Bone Health Changes in a Cohort of Children With Acute Flaccid Myelitis (AFM).Topics in spinal cord injury rehabilitation · 2022Article
- Effect of performing daily activities while standing on the quantity and quality of the thigh muscles in adults with severe cerebral palsy: a cross-sectional study.Journal of physical therapy science · 2021Article
- Assisted standing for Duchenne muscular dystrophy.The Cochrane database of systematic reviews · 2019Review
- Anorexia and supracondylar fracture of the femur following surgery for bilateral lower limb joint contracture in a case of severe cerebral palsy with mental retardation: a case report.Journal of rural medicine : JRM · 2019Article
- A pediatric animal model to evaluate the effects of disuse on musculoskeletal growth and development.Journal of biomechanics · 2016Article
- Fractures in children with cerebral palsy.Current osteoporosis reports · 2014Review
- The frequency of osteogenic activities and the pattern of intermittence between periods of physical activity and sedentary behaviour affects bone mineral content: the cross-sectional NHANES study.BMC public health · 2014Article
- Bone mass and density in preadolescent boys with and without Down syndrome.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2013Article
- Approach to the child with fractures.The Journal of clinical endocrinology and metabolism · 2011Article
- Bone density in cerebral palsy.Physical medicine and rehabilitation clinics of North America · 2009Review
- Puberty, statural growth, and growth hormone release in children with cerebral palsy.Journal of pediatric rehabilitation medicine · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeverely disabled children with cerebral palsy (CP) are prone to low trauma fractures, which are associated with reduced bone mineral density.
aimsTo determine whether participation in 50% longer periods of standing (in either upright or semi-prone standing frames) would lead to an increase in the vertebral and proximal tibial volumetric trabecular bone mineral density (vTBMD) of non-ambulant children with CP.
methodsA heterogeneous group of 26 pre-pubertal children with CP (14 boys, 12 girls; age 4.3-10.8 years) participated in this randomised controlled trial. Subjects were matched into pairs using baseline vertebral vTBMD standard deviation scores. Children within the pairs were randomly allocated to either intervention (50% increase in the regular standing duration) or control (no increase in the regular standing duration) groups. Pre- and post-trial vertebral and proximal tibial vTBMD was measured by quantitative computed tomography (QCT).
resultsThe median standing duration was 80.5% (9.5-102%) and 140.6% (108.7-152.2%) of the baseline standing duration in the control group and intervention group respectively. The mean vertebral vTBMD in the intervention group showed an increase of 8.16 mg/cm3 representing a 6% mean increase in vertebral vTBMD. No change was observed in the mean proximal tibial vTBMD.
conclusionA longer period of standing in non-ambulant children with CP improves vertebral but not proximal tibial vTBMD. Such an intervention might reduce the risk of vertebral fractures but is unlikely to reduce the risk of lower limb fractures in children with CP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.