ArticleEuropean journal of clinical pharmacology2004
Frequency and enzyme activity of the butyrylcholinesterase K-variant in a Turkish population.
Article in European journal of clinical pharmacology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 18 citations in OpenAlex.
- Association of BCHE gene SNP rs1803274 (K-variant) and rs3495 with obesity in Pakistani population group.International journal of obesity (2005) · 2025Article
- Biochemical Analysis and Association of Butyrylcholinesterase SNPs rs3495 and rs1803274 with Substance Abuse Disorder.Journal of molecular neuroscience : MN · 2019Article
- Association between butyrylcholinesterase K variant and mild cognitive impairment in the Thai community-dwelling patients.Clinical interventions in aging · 2017Article
- Gestational diabetes mellitus (GDM) decreases butyrylcholinesterase (BChE) activity and changes its relationship with lipids.Genetics and molecular biology · 2014Article
- Childhood brain tumors, residential insecticide exposure, and pesticide metabolism genes.Environmental health perspectives · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAmong variants of the butyrylcholinesterase gene ( BChE), the K-variant causing Ala539Thr substitution is the most common one associated with about one-third reduction in the enzyme activity. This study aimed to detect the frequency of the K-variant allele in a Turkish population sample and also to evaluate how the plasma BChE activity was influenced by this variant.
methodsPatients administered for elective surgery ( n=77) were examined for the presence of the K allele. The enzyme activity was determined in plasma.
resultsThe K-variant of BChE is a common allele with a frequency of 0.266 (CI(95%) 0.196-0.336) in our sample from a Turkish population. Mean enzyme activity in subjects homozygous for the K-variant was about 40% lower than other subjects.
conclusionThe frequency of the BChE K-variant was significantly higher in a Turkish population than those reported for other populations and it is associated with a diminished enzyme activity.
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