ArticleGenes and immunity2004
An asthma-associated genetic variant of STAT6 predicts low burden of ascaris worm infestation.
Article in Genes and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 76 citations in OpenAlex.
- Association between polymorphisms of IL4, IL13, IL10, STAT6 and IFNG genes, cytokines and immunoglobulin E levels with high burden of Schistosoma mansoni in children from schistosomiasis endemic areas of Cameroon.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2023Article
- The Influence of Genetic and Environmental Factors and Their Interactions on Immune Response to Helminth Infections.Frontiers in immunology · 2022Review
- JAK-STAT signaling in human disease: From genetic syndromes to clinical inhibition.The Journal of allergy and clinical immunology · 2021Review
- Article
- Whipworm and roundworm infections.Nature reviews. Disease primers · 2020Review
- Article
- Particularities of allergy in the Tropics.The World Allergy Organization journal · 2016Review
- Effect of Ascaris lumbricoides infection on T helper cell type 2 in rural Egyptian children.Therapeutics and clinical risk management · 2016Article
- Genetic evidence of regulatory gene variants of the STAT6, IL10R and FOXP3 locus as a susceptibility factor in uncomplicated malaria and parasitaemia in Congolese children.Malaria journal · 2013Article
- Response to infections in patients with asthma and atopic disease: an epiphenomenon or reflection of host susceptibility?The Journal of allergy and clinical immunology · 2012Review
- Maternal geohelminth infections are associated with an increased susceptibility to geohelminth infection in children: a case-control study.PLoS neglected tropical diseases · 2012Article
- Personal and parental nativity as risk factors for food sensitization.The Journal of allergy and clinical immunology · 2012Article
- Evidence for genetic susceptibility to developing early childhood diarrhea among shantytown children living in northeastern Brazil.The American journal of tropical medicine and hygiene · 2011Article
- Acquired immune heterogeneity and its sources in human helminth infection.Parasitology · 2011Review
- Association of rs7719175, located in the IL13 gene promoter, with Schistosoma haematobium infection levels and identification of a susceptibility haplotype.Genes and immunity · 2011Article
- Association between total immunoglobulin E and antibody responses to naturally acquired Ascaris lumbricoides infection and polymorphisms of immune system-related LIG4, TNFSF13B and IRS2 genes.Clinical and experimental immunology · 2009Article
- Localized Th1-, Th2-, T regulatory cell-, and inflammation-associated hepatic and pulmonary immune responses in Ascaris suum-infected swine are increased by retinoic acid.Infection and immunity · 2009Article
- Interactions between helminth parasites and allergy.Current opinion in allergy and clinical immunology · 2009Review
- Anisakis simplex: from obscure infectious worm to inducer of immune hypersensitivity.Clinical microbiology reviews · 2008Review
- A STAT6 gene polymorphism is associated with high infection levels in urinary schistosomiasis.Genes and immunity · 2008Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Th-2 immune mechanisms are involved in the pathology of asthma and in the protective immune response to parasitic worms. Common upregulating genetic variants of Th-2 immune signalling are risk factors for asthma, and we tested whether they may confer a counteradvantage in protecting against parasitic worms. We examined the intensity of infection by the parasitic worm, Ascaris lumbricoides, by microsopic counting of ascaris eggs in the stool of 614 schoolchildren from an area of endemic ascaris infection in China. We investigated the relationship between the intensity of ascaris infection and common, asthma-associated genetic variants of Th-2 and Th-1 immune signalling. Ascaris egg counts per gram of stool (epg), mean 1068 epg, ranged from barely detectable (<240 epg) to heavy (approximately 9600 epg) in a skewed distribution. Logistic regression, after exploratory discriminant analysis, showed a major association between a common genetic variant of the 3'-UTR regulatory elements of the signal transducer and transactivating factor (STAT6) (P=0.0002) and egg counts, at the 77 th centile. Linear regression after log transformation of egg counts confirmed a highly significant association with this STAT6 variant (P=0.001). Thus, a common, asthma-associated, genetic variant of the pivotal transduction and transactivating factor for Th-2 immune signalling, STAT6, predicts increased resistance to ascaris worm infection. The evolution of enhanced resistance to parasitic worm infection, through human genetic variation in Th-2 immune signalling, may represent one origin for asthma.
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