ArticleGenes and immunity2004
Evidence for a cluster of genes on chromosome 17q11-q21 controlling susceptibility to tuberculosis and leprosy in Brazilians.
Article in Genes and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
68 citing papers in PubMed, 3 syntheses or guidelines pooled it, 146 citations in OpenAlex.
- The association between the monocyte Chemoattractant protein-1-2518A/G polymorphism and the risk of tuberculosis in the Chinese population: A meta-analysis and systematic review.Clinics (Sao Paulo, Brazil) · 2025Pooled it
- The association between C-159T polymorphism in CD14 gene and susceptibility to tuberculosis: a meta-analysis.Molecular biology reports · 2014Pooled it
- IFNG +874T/A, IL10 -1082G/A and TNF -308G/A polymorphisms in association with tuberculosis susceptibility: a meta-analysis study.Human genetics · 2008Pooled it
- Lewis Y (LeImmunologic research · 2026Article
- Successful treatment of life-threatening mycobacteriosis using adjunctive gamma-interferon therapy with genetic analysis.IJTLD open · 2024Article
- Article
- The immunogenetics of tuberculosis (TB) susceptibility.Immunogenetics · 2023Review
- Large-Scale Gene Expression Signatures Reveal a Microbicidal Pattern of Activation inFrontiers in immunology · 2021Article
- Genetics and evolution of tuberculosis pathogenesis: New perspectives and approaches.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2020Review
- Exploring the Role of C-C Motif Chemokine Ligand-2 Single Nucleotide Polymorphism in Pulmonary Tuberculosis: A Genetic Association Study from North India.Journal of immunology research · 2020Article
- The Research Progress of Host Genes and Tuberculosis Susceptibility.Oxidative medicine and cellular longevity · 2019Review
- Influence of Genetic Polymorphism Towards Pulmonary Tuberculosis Susceptibility.Frontiers in medicine · 2018Review
- Gene expression and adaptive noncoding changes during human evolution.BMC genomics · 2017Article
- Susceptibility toFrontiers in microbiology · 2017Article
- Genomic Clustering of differential DNA methylated regions (epimutations) associated with the epigenetic transgenerational inheritance of disease and phenotypic variation.BMC genomics · 2016Article
- Relationship of bovine TNF-α gene polymorphisms with the risk of bovine tuberculosis in Holstein cattle.The Journal of veterinary medical science · 2016Article
- Pauci- and Multibacillary Leprosy: Two Distinct, Genetically Neglected Diseases.PLoS neglected tropical diseases · 2016Review
- Differential Requirements for L-Citrulline and L-Arginine during Antimycobacterial Macrophage Activity.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Differential positive selection of malaria resistance genes in three indigenous populations of Peninsular Malaysia.Human genetics · 2015Article
- Chemokine (C-C motif) ligand 5 -28C>G is significantly associated with an increased risk of tuberculosis: a meta-analysis.International journal of clinical and experimental medicine · 2015Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The region of conserved synteny on mouse chromosome 11/human 17q11-q21 is known to carry a susceptibility gene(s) for intramacrophage pathogens. The region is rich in candidates including NOS2A, CCL2/MCP-1, CCL3/MIP-1alpha, CCL4/MIP-1beta, CCL5/RANTES, CCR7, STAT3 and STAT5A/5B. To examine the region in man, we studied 92 multicase tuberculosis (627 individuals) and 72 multicase leprosy (372 individuals) families from Brazil. Multipoint nonparametric analysis (ALLEGRO) using 16 microsatellites shows two peaks of linkage for leprosy at D17S250 (Z(lr) score 2.34; P=0.01) and D17S1795 (Z(lr) 2.67; P=0.004) and a single peak for tuberculosis at D17S250 (Z(lr) 2.04; P=0.02). Combined analysis shows significant linkage (peak Z(lr) 3.38) at D17S250, equivalent to an allele sharing LOD score 2.48 (P=0.0004). To determine whether one or multiple genes contribute, 49 informative single nucleotide polymorphisms were typed in candidate genes. Family-based allelic association testing that was robust to family clustering demonstrated significant associations with tuberculosis susceptibility at four loci separated by intervals (NOS2A-8.4 Mb-CCL18-32.3 kb-CCL4-6.04 Mb-STAT5B) up to several Mb. Stepwise conditional logistic regression analysis using a case/pseudo-control data set showed that the four genes contributed separate main effects, consistent with a cluster of susceptibility genes across 17q11.2.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.