ArticleProceedings of the National Academy of Sciences of the United States of America2004
Control of calcium oscillations by membrane fluxes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 136 citations in OpenAlex.
- Review
- A molecular systems perspective on calcium oscillations beyond ion fluxes.Current opinion in cell biology · 2025Review
- A Model for the Coexistence of Competing Mechanisms forBulletin of mathematical biology · 2024Article
- Intracellular Calcium Dynamics in Primary Human Adrenocortical Cells Deciphered with a Novel Pipeline.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2024Article
- Calcium oscillations in HEK293 cells lacking SOCE suggest the existence of a balanced regulation of IPFrontiers in systems biology · 2024Article
- An integrate-and-fire approach to CaBiophysical journal · 2023Article
- Omnitemporal choreographies of all five STIM/Orai and IPCell reports · 2021Article
- CaAmerican journal of physiology. Cell physiology · 2020Article
- Modeling the role of endoplasmic reticulum-mitochondria microdomains in calcium dynamics.Scientific reports · 2019Article
- Estradiol-Mediated Axogenesis of Hypothalamic Neurons Requires ERK1/2 and Ryanodine Receptors-Dependent Intracellular CaFrontiers in cellular neuroscience · 2019Article
- CaThe Journal of physiology · 2018Article
- Variable setpoint as a relaxing component in physiological control.Physiological reports · 2017Article
- Mathematical investigation of IPJournal of computational neuroscience · 2017Article
- The relative contributions of store-operated and voltage-gated CaThe Journal of physiology · 2017Article
- Feedback, Mass Conservation and Reaction Kinetics Impact the Robustness of Cellular Oscillations.PLoS computational biology · 2016Article
- Nuclear pores enable sustained perinuclear calcium oscillations.BMC systems biology · 2016Article
- Cellular Architecture Regulates Collective Calcium Signaling and Cell Contractility.PLoS computational biology · 2016Article
- Routes of Ca2+ Shuttling during Ca2+ Oscillations: FOCUS ON THE ROLE OF MITOCHONDRIAL Ca2+ HANDLING AND CYTOSOLIC Ca2+ BUFFERS.The Journal of biological chemistry · 2015Article
- Calcium signalling in Cajal-like interstitial cells of the lower urinary tract.Nature reviews. Urology · 2014Review
- A deterministic model predicts the properties of stochastic calcium oscillations in airway smooth muscle cells.PLoS computational biology · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
It is known that Ca(2+) influx plays an important role in the modulation of inositol trisphosphate-generated Ca(2+) oscillations, but controversy over the mechanisms underlying these effects exists. In addition, the effects of blocking membrane transport or reducing Ca(2+) entry vary from one cell type to another; in some cell types oscillations persist in the absence of Ca(2+) entry (although their frequency is affected), whereas in other cell types oscillations depend on Ca(2+) entry. We present theoretical and experimental evidence that membrane transport can control oscillations by controlling the total amount of Ca(2+) in the cell (the Ca(2+) load). Our model predicts that the cell can be balanced at a point where small changes in the Ca(2+) load can move the cell into or out of oscillatory regions, resulting in the appearance or disappearance of oscillations. Our theoretical predictions are verified by experimental results from HEK293 cells. We predict that the role of Ca(2+) influx during an oscillation is to replenish the Ca(2+) load of the cell. Despite this prediction, even during the peak of an oscillation the cell or the endoplasmic reticulum may not be measurably depleted of Ca(2+).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.