ArticleProceedings of the National Academy of Sciences of the United States of America2004
A genomewide oscillation in transcription gates DNA replication and cell cycle.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 148 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
148 citing papers in PubMed, 333 citations in OpenAlex.
- The chromosomal origin of replication as the basis for the spatio-temporal biology of bacteria.Frontiers in microbiology · 2026Review
- Temporal oscillation of phospholipids promotes metabolic efficiency.Nature chemical biology · 2025Article
- A four eigen-phase model of multi-omics unveils new insights into yeast metabolic cycle.NAR genomics and bioinformatics · 2025Article
- Regulation of transcription elongation anticipates alternative gene expression strategies across the cell cycle.PloS one · 2025Article
- Hypothesis: bacteria live on the edge of phase transitions with a cell cycle regulated by a water-clock.Theory in biosciences = Theorie in den Biowissenschaften · 2024Article
- Whole genome regulatory effect ofmBio · 2024Article
- Studying the Human Microbiota: Advances in Understanding the Fundamentals, Origin, and Evolution of Biological Timekeeping.International journal of molecular sciences · 2023Review
- The metabolic control of DNA replication: mechanism and function.Open biology · 2023Review
- Temporal segregation of biosynthetic processes is responsible for metabolic oscillations during the budding yeast cell cycle.Nature metabolism · 2023Article
- Pyruvate kinase, a metabolic sensor powering glycolysis, drives the metabolic control of DNA replication.BMC biology · 2022Article
- Cancer cell metabolism connects epigenetic modifications to transcriptional regulation.The FEBS journal · 2022Review
- Recognition of acetylated histone by Yaf9 regulates metabolic cycling of transcription initiation and chromatin regulatory factors.Genes & development · 2021Article
- Autonomous clocks that regulate organelle biogenesis, cytoskeletal organization, and intracellular dynamics.eLife · 2021Review
- Peroxiredoxins couple metabolism and cell division in an ultradian cycle.Nature chemical biology · 2021Article
- Article
- Self-Organization and Information Processing: From Basic Enzymatic Activities to Complex Adaptive Cellular Behavior.Frontiers in genetics · 2021Review
- Glucocorticoid-Mediated Developmental Programming of Vertebrate Stress Responsivity.Frontiers in physiology · 2021Review
- Multiple Rediscoveries and Misconceptions; the Yeast Metabolic Oscillation.Function (Oxford, England) · 2021Article
- Glucocorticoid-Responsive Transcription Factor Krüppel-Like Factor 9 RegulatesFrontiers in cell and developmental biology · 2021Article
- Eukaryotic cell biology is temporally coordinated to support the energetic demands of protein homeostasis.Nature communications · 2020Article
88 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microarray analysis from a yeast continuous synchrony culture system shows a genomewide oscillation in transcription. Maximums in transcript levels occur at three nearly equally spaced intervals in this approximately 40-min cycle of respiration and reduction. Two temporal clusters (4,679 of 5,329) are maximally expressed during the reductive phase of the cycle, whereas a third cluster (650) is maximally expressed during the respiratory phase. Transcription is organized functionally into redox-state superclusters with genes known to be important in respiration or reduction being synthesized in opposite phases of the cycle. The transcriptional cycle gates synchronous bursts in DNA replication in a constant fraction of the population at 40-min intervals. Restriction of DNA synthesis to the reductive phase of the cycle may be an evolutionarily important mechanism for reducing oxidative damage to DNA during replication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.