ArticleProceedings of the National Academy of Sciences of the United States of America2004
Ly49Q, a member of the Ly49 family that is selectively expressed on myeloid lineage cells and involved in regulation of cytoskeletal architecture.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 48 citations in OpenAlex.
- Hematopoietic Stem and Progenitor Cells Establish Dynamic Podosome-Like Structures to Interact with Fibronectin.Advanced biology · 2026Article
- Functions of Sulfatide in the Nervous, Immune, and Urinary Systems.Advances in experimental medicine and biology · 2026Review
- Collaboration between a cis-interacting natural killer cell receptor and membrane sphingolipid is critical for the phagocyte function.Frontiers in immunology · 2024Article
- Ly49 receptors: innate and adaptive immune paradigms.Frontiers in immunology · 2014Review
- The ly49 gene family. A brief guide to the nomenclature, genetics, and role in intracellular infection.Frontiers in immunology · 2013Article
- Transcriptional profiling of human monocytes identifies the inhibitory receptor CD300a as regulator of transendothelial migration.PloS one · 2013Article
- Signaling by myeloid C-type lectin receptors in immunity and homeostasis.Annual review of immunology · 2012Review
- Inhibitory C-type lectin receptors in myeloid cells.Immunology letters · 2011Review
- Article
- Effects of MHC class I alleles on licensing of Ly49A+ NK cells.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Positive regulation of plasmacytoid dendritic cell function via Ly49Q recognition of class I MHC.The Journal of experimental medicine · 2008Article
- NK gene complex dynamics and selection for NK cell receptors.Seminars in immunology · 2008Review
- Cis interactions of immunoreceptors with MHC and non-MHC ligands.Nature reviews. Immunology · 2008Review
- Comparative genomics of natural killer cell receptor gene clusters.PLoS genetics · 2005Article
- Direct sequence comparison of two divergent class I MHC natural killer cell receptor haplotypes.Genes and immunity · 2005Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here, we identified and characterized a Ly49 family member, designated as Ly49Q. The Ly49q gene encodes a 273-aa protein with an immunoreceptor tyrosine-based inhibitory motif (ITIM) at the N terminus of its cytoplasmic domain. We show that the ITIM of Ly49Q can recruit SHP-2 and SHP-1 in a tyrosine phosphorylation-dependent manner. In contrast to other known members of the Ly49 family, Ly49Q was found not to be expressed on NK1.1(+) cells, but instead was detectable on virtually all Gr-1(+) cells, such as myeloid precursors in bone marrow. Monocytes/macrophages also expressed low levels of Ly49Q, and the expression was enhanced by the treatment of cells with IFN-gamma. Treatment of activated macrophages with anti-Ly49Q mAb induced rapid formation of polarized actin structures, showing filopodia-like structure on one side and lamellipodial-like structure on the other side. A panel of proteins became tyrosine-phosphorylated in myeloid cells when treated with the mAb. Induction of the phosphorylation depends on the ITIM of Ly49Q. Thus, Ly49Q has unique features different from other known Ly49 family members and appears to be involved in regulation of cytoskeletal architecture of macrophages through ITIM-mediated signaling.
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