ArticlePlant physiology2004
Calcium sensors and their interacting protein kinases: genomics of the Arabidopsis and rice CBL-CIPK signaling networks.
Article in Plant physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It carries an expression of concern. Cited by 236 papers, 1 of them a synthesis that pooled it.
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236 citing papers in PubMed, 1 synthesis or guideline pooled it, 616 citations in OpenAlex.
- Primary nitrate responses mediated by calcium signalling and diverse protein phosphorylation.Journal of experimental botany · 2020Pooled it
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- The SlCBL-SlCML24 module mediates silicon-enhanced resistance to bacterial wilt in Solanum lycopersicum.Plant cell reports · 2026Article
- Comprehensive analysis of CBL and CIPK gene families in Magnolia biondii and functional characterization of MbCBL4 under salt stress.Plant cell reports · 2026Article
- Characterization of McCIPK6, a mitochondrial protein, positively regulating cold stress tolerance in bitter gourd (Frontiers in plant science · 2026Article
- LjCIPK1: a CBL-interacting protein kinase fromFrontiers in plant science · 2026Article
- Genome-wide characterization of theFrontiers in plant science · 2026Article
- Comparative transcriptome profiling reveals molecular mechanisms of freezing stress responses in cultivated and wild Cicer species.Scientific reports · 2025Article
- Decoding the CBL gene family in durum wheat: Insights into dual ABA signaling pathways and calcium-mediated drought tolerance.The plant genome · 2025Article
- SOS3 fromCells · 2025Article
- Genome-wide analysis of CBL and CIPK gene families in bermudagrass reveals the CdCIPK29-A1 as a stem growth angle regulator.Plant cell reports · 2025Article
- Genomic signatures of SnRKs highlighted conserved evolution within orchids and stress responses through ABA signaling in the Cymbidium ensifolium.BMC plant biology · 2025Article
- Evolution and functional characterization of Populus salt stress-responsive calcineurin B-like protein-interacting protein kinases.Plant cell reports · 2024Article
- An Enhanced Interaction of Graft and Exogenous SA on Photosynthesis, Phytohormone, and Transcriptome Analysis in Tomato under Salinity Stress.International journal of molecular sciences · 2024Article
- Calcium-Dependent Protein Kinase GhCDPK16 Exerts a Positive Regulatory Role in Enhancing Drought Tolerance in Cotton.International journal of molecular sciences · 2024Article
- Evolution and subfunctionalization of CIPK6 homologous genes in regulating cotton drought resistance.Nature communications · 2024Article
- Structural and molecular dynamics simulation studies of CBL-interacting protein kinase CIPK and its complexes related to plant salinity stress.Journal of molecular modeling · 2024Article
- Integrative gene duplication and genome-wide analysis as an approach to facilitate wheat reverse genetics: An example in the TaCIPK family.Journal of advanced research · 2024Article
- Genome-Wide Identification of Members of the SoybeanPlants (Basel, Switzerland) · 2024Article
176 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
- Expression of concern
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcium signals mediate a multitude of plant responses to external stimuli and regulate a wide range of physiological processes. Calcium-binding proteins, like calcineurin B-like (CBL) proteins, represent important relays in plant calcium signaling. These proteins form a complex network with their target kinases being the CBL-interacting protein kinases (CIPKs). Here, we present a comparative genomics analysis of the full complement of CBLs and CIPKs in Arabidopsis and rice (Oryza sativa). We confirm the expression and transcript composition of the 10 CBLs and 25 CIPKs encoded in the Arabidopsis genome. Our identification of 10 CBLs and 30 CIPKs from rice indicates a similar complexity of this signaling network in both species. An analysis of the genomic evolution suggests that the extant number of gene family members largely results from segmental duplications. A phylogenetic comparison of protein sequences and intron positions indicates an early diversification of separate branches within both gene families. These branches may represent proteins with different functions. Protein interaction analyses and expression studies of closely related family members suggest that even recently duplicated representatives may fulfill different functions. This work provides a basis for a defined further functional dissection of this important plant-specific signaling system.
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