ArticleMolecular and cellular biology2004
Novel isotypic gamma/zeta subunits reveal three coatomer complexes in mammals.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 52 citations in OpenAlex.
- Deficiency in coatomer complex I causes aberrant activation of STING signalling.Nature communications · 2022Article
- Shared and specific functions of Arfs 1-5 at the Golgi revealed by systematic knockouts.The Journal of cell biology · 2022Article
- Article
- A paralog-specific role of COPI vesicles in the neuronal differentiation of mouse pluripotent cells.Life science alliance · 2020Article
- Loss ofFrontiers in plant science · 2020Article
- Crystal structure of truncated human coatomer protein complex subunit ζ1 (Copζ1).Acta crystallographica. Section F, Structural biology communications · 2017Article
- Golgi-situated endoplasmic reticulum α-1, 2-mannosidase contributes to the retrieval of ERAD substrates through a direct interaction with γ-COP.Molecular biology of the cell · 2013Article
- Retrograde vesicle transport in the Golgi.Protoplasma · 2012Review
- Abortive autophagy induces endoplasmic reticulum stress and cell death in cancer cells.PloS one · 2012Article
- COPI budding within the Golgi stack.Cold Spring Harbor perspectives in biology · 2011Review
- Phenotypic profiling of the human genome reveals gene products involved in plasma membrane targeting of SRC kinases.Genome research · 2011Article
- Several ADP-ribosylation factor (Arf) isoforms support COPI vesicle formation.The Journal of biological chemistry · 2011Article
- Article
- The function of the intermediate compartment in pre-Golgi trafficking involves its stable connection with the centrosome.Molecular biology of the cell · 2009Article
- Following the fate in vivo of COPI vesicles generated in vitro.Traffic (Copenhagen, Denmark) · 2009Article
- Three homologous ArfGAPs participate in coat protein I-mediated transport.The Journal of biological chemistry · 2009Article
- A COPI coat subunit interacts directly with an early-Golgi localized Arf exchange factor.EMBO reports · 2009Article
- Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI trafficking.The Journal of cell biology · 2008Article
- gammaCOP is required for apical protein secretion and epithelial morphogenesis in Drosophila melanogaster.PloS one · 2008Article
- COPI-mediated transport.The Journal of membrane biology · 2006Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In early secretory transport, coat recruitment for the formation of coat protein I (COPI) vesicles involves binding to donor Golgi membranes of the small GTPase ADP-ribosylation factor 1 and subsequent attachment of the cytoplasmic heptameric complex coatomer. Various hypotheses exist as to the precise role of and possible routes taken by COPI vesicles in the mammalian cell. Here we report the ubiquitous expression of two novel isotypes of coatomer subunits gamma- and zeta-COP that are incorporated into coatomer, and show that three isotypes exist of the complex defined by the subunit combinations gamma 1/zeta 1, gamma 1/zeta 2, and gamma 2/zeta 1. In a liver cytosol, these forms make up the total coatomer in a ratio of about 2:1:2, respectively. The coatomer isotypes are located differentially within the early secretory pathway, and the gamma 2/zeta 1 isotype is preferentially incorporated into COPI vesicles. A population of COPI vesicles was characterized that almost exclusively contains gamma 2/zeta 1 coatomer. This existence of three structurally different forms of coatomer will need to be considered in future models of COPI-mediated transport.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.