ArticleMolecular and cellular biology2004
Identification of MoKA, a novel F-box protein that modulates Krüppel-like transcription factor 7 activity.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 53 citations in OpenAlex.
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- FBXO38 is dispensable for PD-1 regulation.EMBO reports · 2024Article
- Identification and experimental validation of hub genes underlying depressive-like behaviors induced by chronic social defeat stress.Frontiers in pharmacology · 2024Article
- Krüppel-like factor 7 deficiency disrupts corpus callosum development and neuronal migration in the developing mouse cerebral cortex.Brain pathology (Zurich, Switzerland) · 2023Article
- Molecular function of Krüppel-like factor 7 in biology.Acta biochimica et biophysica Sinica · 2023Review
- KLF7 promotes preadipocyte proliferation via activation of the Akt signaling pathway byActa biochimica et biophysica Sinica · 2022Article
- Obesity-induced elevated palmitic acid promotes inflammation and glucose metabolism disorders through GPRs/NF-κB/KLF7 pathway.Nutrition & diabetes · 2022Article
- Krüppel-like Transcription Factor 7 Is a Causal Gene in Autism Development.International journal of molecular sciences · 2022Article
- FBXO38 Ubiquitin Ligase Controls Centromere Integrity via ZXDA/B Stability.Frontiers in cell and developmental biology · 2022Article
- FBXO38 Ubiquitin Ligase Controls Sertoli Cell Maturation.Frontiers in cell and developmental biology · 2022Article
- The Role of Cullin-RING Ligases in Striated Muscle Development, Function, and Disease.International journal of molecular sciences · 2020Review
- Analysis of genetically driven alternative splicing identifies FBXO38 as a novel COPD susceptibility gene.PLoS genetics · 2019Article
- Combining CDKN1A gene expression and genome-wide SNPs in a twin cohort to gain insight into the heritability of individual radiosensitivity.Functional & integrative genomics · 2019Article
- Toxoplasma F-box protein 1 is required for daughter cell scaffold function during parasite replication.PLoS pathogens · 2019Article
- USP7 Regulates Cytokinesis through FBXO38 and KIF20B.Scientific reports · 2019Article
- The Effect and Mechanism of KLF7 in the TLR4/NF-Mediators of inflammation · 2018Article
- Article
- Hey bHLH Proteins Interact with a FBXO45 Containing SCF Ubiquitin Ligase Complex and Induce Its Translocation into the Nucleus.PloS one · 2015Article
- Spinal cord injury and the neuron-intrinsic regeneration-associated gene program.Neuromolecular medicine · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
KLF7, a member of the Krüppel-like transcription factor family, is believed to regulate neurogenesis and cell cycle progression. Here, a yeast two-hybrid screen for KLF7 cofactors in the developing nervous system identified a novel 140-kDa protein named MoKA, for modulator of KLF7 activity. Interaction between MoKA and KLF7 was confirmed by the in vitro glutathione S-transferase pull-down assay and by coimmunoprecipitation of the proteins overexpressed in mammalian cells. Functional assays documented that MoKA is a KLF7 coactivator, and in situ hybridizations identified the developing nervous system and the adult testes as two sites of MoKA and Klf7 coexpression. Chromatin immunoprecipitation experiments demonstrated KLF7 binding to the p21(WAF1/Cip1) gene while transient transfection assays documented KLF7 stimulation of the p21(WAF1/Cip1) proximal promoter. Additional tests revealed that distinct structural motifs of MoKA direct interaction with KLF7 and shuttling between the nucleus and cytoplasm of asynchronously cycling cells. Altogether, our results strongly suggest that MoKA and KLF7 interact functionally to regulate gene expression during cell differentiation and identify the cell cycle regulator p21(WAF1/Cip1) as one of the targeted genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.