ArticlePflugers Archiv : European journal of physiology2004
Induced automaticity in isolated rat atrial cells by incorporation of a stretch-activated conductance.
Article in Pflugers Archiv : European journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Maternal focal atrial tachycardia during pregnancy: A systematic review.Journal of cardiovascular electrophysiology · 2020Pooled it
- Ivabradine-sensitive incessant atrial tachycardia during pregnancy: a case report.European heart journal. Case reports · 2021Article
- Heterogeneity of calcium clock functions in dormant, dysrhythmically and rhythmically firing single pacemaker cells isolated from SA node.Cell calcium · 2018Article
- Depolarization-induced automaticity in rat ventricular cardiomyocytes is based on the gating properties of L-type calcium and slow Kv channels.European biophysics journal : EBJ · 2013Article
- Transient outward K+ current reduction prolongs action potentials and promotes afterdepolarisations: a dynamic-clamp study in human and rabbit cardiac atrial myocytes.The Journal of physiology · 2012Article
- Stretch-activated channel activation promotes early afterdepolarizations in rat ventricular myocytes under oxidative stress.American journal of physiology. Heart and circulatory physiology · 2009Article
- Modeling of arrhythmogenic automaticity induced by stretch in rat atrial myocytes.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2008Article
- Dynamic clamp: a powerful tool in cardiac electrophysiology.The Journal of physiology · 2006Review
- 'Dynamic clamp' in cardiac electrophysiology.The Journal of physiology · 2005Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Stretch of the atrium and sympathetic activity have been implicated as substrates for atrial fibrillation. We investigate how a model of stretch in combination with sympathetic stimulation can induce automaticity in atrial cells. We adapted our coupling clamp circuit so that a model ionic current that represents stretch-activated channels (SACs) was injected into an isolated rat atrial cell in real time. This current was calculated as ISAC= GSAC (Vm-ESAC), where GSAC and ESAC are the conductance and reversal potential of SACs and Vm is the cell's membrane potential. Repetitive automaticity was induced by a sufficiently large GSAC and this critical value of GSAC was decreased by exposure to isoproterenol. The critical value of GSAC decreased from 0.63+/-0.05 nS (mean+/-SE) in control to 0.40+/-0.07 nS in isoproterenol (P<0.05). Additionally, after exposure to isoproterenol, automaticity continued after GSAC was no longer applied and was accompanied by delayed after-depolarizations. In three cells, repetitive automaticity could not be induced at any value of GSAC. Exposure to 10 nM isoproterenol converted these cells to cells with repetitive automaticity in response to GSAC. We conclude that automaticity can be induced in isolated rat atrial cells by application of a model of SACs. Exposure to isoproterenol enhances this effect.
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