ArticleDevelopment genes and evolution2004
An enhancer-trap LacZ transgene reveals a distinct expression pattern of Kinesin family 26B in mouse embryos.
Article in Development genes and evolution, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Revealing study and breeding implications for production traits and tail characteristics in Simmental cattle by GWAS.Frontiers in genetics · 2025Article
- KIF26B Silencing Prevents Osseous Transdifferentiation of Progenitor/Stem Cells and Attenuates Ectopic Calcification in a Murine Model.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
- Novel genetic associations with five aesthetic facial traits: A genome-wide association study in the Chinese population.Frontiers in genetics · 2022Article
- Diverse spinal commissural neuron populations revealed by fate mapping and molecular profiling using a novel Robo3The Journal of comparative neurology · 2019Article
- De novo variant in KIF26B is associated with pontocerebellar hypoplasia with infantile spinal muscular atrophy.American journal of medical genetics. Part A · 2018Article
- Upregulation of KIF26B, Cell Migration and Proliferation of Human Ovarian Cancer Cell Lines In Vitro, and Patient Outcomes from Human Bioinformatic Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- MiR-20a-5p represses multi-drug resistance in osteosarcoma by targeting the KIF26B gene.Cancer cell international · 2016Article
- Elevated kinesin family member 26B is a prognostic biomarker and a potential therapeutic target for colorectal cancer.Journal of experimental & clinical cancer research : CR · 2015Article
- Article
- Deficiency in Six2 during prenatal development is associated with reduced nephron number, chronic renal failure, and hypertension in Br/+ adult mice.American journal of physiology. Renal physiology · 2009Article
- Ectopic expression of mouse Sry interferes with Wnt/beta-catenin signaling in mouse embryonal carcinoma cell lines.Biochimica et biophysica acta · 2008Article
- Misexpression of Six2 is associated with heritable frontonasal dysplasia and renal hypoplasia in 3H1 Br mice.Developmental dynamics : an official publication of the American Association of Anatomists · 2008Article
- Identification of genes differentially expressed during prenatal development of skeletal muscle in two pig breeds differing in muscularity.BMC developmental biology · 2007Article
- A genomic screen for activators of the antioxidant response element.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
The enhancer-trap system is a useful tool to uncover genes that exhibit a unique tissue-specific expression. Here, we established a transgenic mouse line in which the reporter gene LacZ was specifically expressed in the developing limbs and face in the embryo. To identify the endogenous genes that are controlled by the limb- and face-specific enhancers, we pinpointed the integration site of the transgene, and analyzed the expression pattern of the genes that were located near the integration site. We found that the gene encoding KIF26B, a member of the kinesin superfamily, was preferentially expressed in the limb buds, face, and somite derivatives. Moreover, while a 7.5-kb mRNA was the major Kif26B transcript in the embryo, it was absent in many adult tissues. These results imply that KIF26B may play a role in embryogenesis, specifically in the development of limbs, face, and somites.
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