ArticleJournal of perinatology : official journal of the California Perinatal Association2004
Association of glutathione-S-transferase-P1 (GST-P1) polymorphisms with bronchopulmonary dysplasia.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 79 citations in OpenAlex.
- Perinatal glucocorticoid sensitivity in the preterm newborn: molecular mechanisms, endogenous determinants, and clinical implications.Frontiers in endocrinology · 2025Review
- Headway and the remaining hurdles of mesenchymal stem cells therapy for bronchopulmonary dysplasia.The clinical respiratory journal · 2022Review
- Cardiopulmonary Exercise Testing in Childhood in Late Preterms: Comparison to Early Preterms and Term-Born Controls.Journal of personalized medicine · 2022Article
- Verification of immunology-related genetic associations in BPD supports ABCA3 and five other genes.Pediatric research · 2022Article
- Evaluation of Genetic Polymorphisms of the Antioxidant Enzymes and Biomarkers of Oxidative Stress in Preterm Neonates With Respiratory Distress Syndrome Receiving External Surfactant.Biomarker insights · 2022Article
- Assessment of toxicological consequences upon acute inhalation exposure to chemically improvised nonlethal riot control combinational formulation (NCF) containing oleoresin capsicum and skatole.Toxicology research · 2021Article
- Aurothioglucose enhances proangiogenic pathway activation in lungs from room air and hyperoxia-exposed newborn mice.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- Potential therapeutic targets in Nrf2-dependent protection against neonatal respiratory distress disease predicted by cDNA microarray analysis and bioinformatics tools.Current opinion in toxicology · 2016Article
- Recurrent copy number variants associated with bronchopulmonary dysplasia.Pediatric research · 2016Article
- Association of Nrf2 with airway pathogenesis: lessons learned from genetic mouse models.Archives of toxicology · 2015Review
- The role of genetic polymorphisms in antioxidant enzymes and potential antioxidant therapies in neonatal lung disease.Antioxidants & redox signaling · 2014Review
- Antioxidant strategies and respiratory disease of the preterm newborn: an update.Oxidative medicine and cellular longevity · 2014Review
- Glutathion-S-Transferase P1 polymorphisms association with broncopulmonary dysplasia in preterm infants.Hippokratia · 2013Article
- Association of a FGFR-4 gene polymorphism with bronchopulmonary dysplasia and neonatal respiratory distress.Disease markers · 2013Article
- Identification of SPOCK2 as a susceptibility gene for bronchopulmonary dysplasia.American journal of respiratory and critical care medicine · 2011Article
- Genetics of bronchopulmonary dysplasia in the age of genomics.Current opinion in pediatrics · 2010Review
- Glutathione-S-transferase-P1 I105V polymorphism and response to antenatal betamethasone in the prevention of respiratory distress syndrome.European journal of clinical pharmacology · 2009Article
- Article
- Heritability of bronchopulmonary dysplasia, defined according to the consensus statement of the national institutes of health.Pediatrics · 2008Article
- Association of glutathione-S-transferase-P1 (GSTP1) polymorphism 105 Ile>val with chronic lung disease in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2004Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveReactive oxygen species (ROS) contribute to oxidative lung injury. The glutathione-S-transferases (GST) family and microsomal epoxide hydrolase (mEPHx) enzymes detoxify ROS, and genetic polymorphisms alter this detoxification. We hypothesized that polymorphisms encoding for less efficient enzymes were associated with bronchopulmonary dysphasia (BPD). STUDY
designWe determined allelic distribution of these polymorphisms in a pilot study of 35 BPD cases and 98 controls. chi2 and regression analysis were performed.
resultsGST P1 val105ile distribution differed between the groups, with the more efficient val/val allele predominantly in controls (p< or =0.05). When controlling for race and sex, BPD cases were less likely to be homozygotes for the val/val isoform (OR 0.21, CI: 0.045-0.95, p=0.04) and more likely to possess the less efficient ile isoform (OR 4.5, CI: 1.0-20.7, p=0.05).
conclusionsThis pilot study suggests that BPD is associated with the presence of the GST-P1 105ile allele. Future prospective studies are warranted.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.