Receptor tyrosine kinase signaling and primordial germ cell development.

Willis X Li

Open access · bronzeAbstract read

In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

0.3field-weighted citation impact, top 43% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

Reactive oxygen species signaling in primordial germ cell development in Drosophila embryos.Genesis (New York, N.Y. : 2000) · 2020
Article
Dedifferentiating spermatogonia outcompete somatic stem cells for niche occupancy in the Drosophila testis.Cell stem cell · 2009
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Willis X LiDepartment of Biomedical Genetics, University of Rochester Medical Center, 601 Elmwood Ave., Box 633, Rochester, New York 14642, USA. willis_li@urmc.rochester.edu

University of Rochester Medical Center · US

Funding

Genetic Analysis of Intracellular Signaling CrosstalkR01GM065774 · NIGMS · UNIVERSITY OF ROCHESTER · PI LI, WILLIS X · 2002 to 2006

$1.3M

Network Interaction between EGFR and TGFbeta PathwaysR01GM077046 · NIGMS · UNIVERSITY OF ROCHESTER · PI LI, WILLIS X · 2006 to 2009

$940k

NIGMS NIH HHS R01 GM065774NIGMS NIH HHS R01 GM077046

6 · The paper itself

Abstract

Primordial germ cells (PGCs) give rise to sperms and eggs. Their development is crucial to species propagation and has to be precisely controlled. Studies in several model organisms have identified many genes involved in the specification and guided migration of PGCs. However, the mechanisms governing the behaviors of these unique cells remain to be investigated. Interestingly, PGCs share certain cellular properties with metastasizing cancer cells including proliferation, invasion of other tissues, survival and migration. Recently we have shown that in Drosophila the receptor tyrosine kinase Torso activates both STAT and Ras during the early phase of PGC development. In later stages, activation of both STAT and Ras, likely by other molecules, is required continuously for PGC migration. The requirement for RTK suggests molecular conservation between flies and mice in PGC development and also suggests that germ cells and cancer cells share certain intracellular signaling strategies.

Indexed as

Cell DifferentiationSignal TransductionAnimalsDrosophila melanogasterGerm CellsReceptor Protein-Tyrosine KinasesReceptor Protein-Tyrosine Kinases

Identifiers

PMID14726648

PMCPMC3090257

OpenAlexW1993791581

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.