ArticlePharmaceutical research2003
Thermosensitive hydrogel as a Tgf-beta1 gene delivery vehicle enhances diabetic wound healing.
Article in Pharmaceutical research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 128 citations in OpenAlex.
- Polyphosphate-crosslinked hydrogels: structural design and bioactivity for tissue engineering scaffolds.RSC advances · 2026Article
- Thermo-Sensitive Polymeric Networks for Next-Generation Wound Management: A Review.AAPS PharmSciTech · 2026Review
- Smart microdevices for biomedical drug delivery: endogenous stimuli as the key to safer therapeutics.RSC advances · 2026Review
- Designing Composite Stimuli-Responsive Hydrogels for Wound Healing Applications: The State-of-the-Art and Recent Discoveries.Materials (Basel, Switzerland) · 2024Review
- Therapeutic role of growth factors in treating diabetic wound.World journal of diabetes · 2023Review
- Efficiency of Multifunctional Antibacterial Hydrogels for Chronic Wound Healing in Diabetes: A Comprehensive Review.International journal of nanomedicine · 2022Review
- Translational Applications of Hydrogels.Chemical reviews · 2021Review
- Limited Treatment Options for Diabetic Wounds: Barriers to Clinical Translation Despite Therapeutic Success in Murine Models.Advances in wound care · 2021Article
- (Macro)molecular self-assembly for hydrogel drug delivery.Advanced drug delivery reviews · 2021Review
- Innovations in gene and growth factor delivery systems for diabetic wound healing.Journal of tissue engineering and regenerative medicine · 2018Review
- Extracellular Matrix-Inspired Growth Factor Delivery Systems for Skin Wound Healing.Advances in wound care · 2015Review
- Bioactive factor delivery strategies from engineered polymer hydrogels for therapeutic medicine.Progress in polymer science · 2014Article
- The PEG-PCL-PEG Hydrogel as an Implanted Ophthalmic Delivery System after Glaucoma Filtration Surgery; a Pilot Study.Medical hypothesis, discovery & innovation ophthalmology journal · 2014Article
- Materials that harness and modulate the immune system.MRS bulletin · 2014Article
- Matrix metalloproteinase-inspired suicidal treatments of diabetic ulcers with siRNA-decorated nanofibrous meshes.Gene therapy · 2013Article
- Drug-loaded polymeric composite skin graft for infection-free wound healing: fabrication, characterization, cell proliferation, migration, and antimicrobial activity.Pharmaceutical research · 2012Article
- Fibrin hydrogels for lentiviral gene delivery in vitro and in vivo.Journal of controlled release : official journal of the Controlled Release Society · 2012Article
- Biomaterial selection for tooth regeneration.Tissue engineering. Part B, Reviews · 2011Review
- Materials for pharmaceutical dosage forms: molecular pharmaceutics and controlled release drug delivery aspects.International journal of molecular sciences · 2010Review
- Non-viral gene delivery transfection profiles influence neuronal architecture in an in vitro co-culture model.Biotechnology and bioengineering · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo accelerate diabetic wound healing with TGF-beta1 gene delivery system using a thermosensitive hydrogel made of a triblock copolymer, PEG-PLGA-PEG.
methodsTwo 7 x 7 mm full thickness excisional wounds were created in parallel at the back of each genetically diabetic mouse. The hydrogel containing plasmid TGF-beta1 was administered to the wound and formed an adhesive film in situ. Controls were either untreated or treated with the hydrogel without DNA. We used a commercial wound dressing, Humatrix, either with or without DNA, to compare the therapeutic effect with the thermosensitive hydrogel.
resultsWe found that thermosensitive hydrogel alone is slightly beneficial for reepithealization at early stage of healing (day 1-5), but significantly accelerated repithelializaion, increased cell proliferation, and organized collagen were observed in the wound bed treated with thermosensitive hydrogel containing plasmid TGF-beta1. The accelerated reepithelialization was accompanied with enhanced collagen synthesis and more organized extracellular matrix deposition. Humatrix alone or with plasmid TGF-beta1, had little effect.
conclusionsThermosensitive hydrogel made of PEG-PLGA-PEG triblock copolymer provides excellent wound dressing activity and delivers plasmid TGF-beta1 to promote wound healing in a diabetic mouse model.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.