ArticleThe Journal of membrane biology2003
Electrostatic influence on ion transport through the alphaHL channel.
Article in The Journal of membrane biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Bioinformatic and computational biophysics tools for nanopore engineering: a review from standard approaches to machine learning advancements.Journal of nanobiotechnology · 2026Review
- Nanopore sensing: A physical-chemical approach.Biochimica et biophysica acta. Biomembranes · 2021Review
- Nanopore Fabrication and Application as Biosensors in Neurodegenerative Diseases.Critical reviews in biomedical engineering · 2020Review
- High Resolution Physical Characterization of Single Metallic Nanoparticles.Journal of visualized experiments : JoVE · 2019Article
- Rapid and Accurate Determination of Nanopore Ionic Current Using a Steric Exclusion Model.ACS sensors · 2019Article
- Comparative biosensing of glycosaminoglycan hyaluronic acid oligo- and polysaccharides using aerolysin andThe European physical journal. E, Soft matter · 2018Article
- Membrane Position Dependency of the pKThe Journal of membrane biology · 2018Article
- Dramatic pressure-sensitive ion conduction in conical nanopores.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Molecular dynamics simulation of water permeation through the alpha-hemolysin channel.Journal of biological physics · 2016Article
- Temperature Effect on Ionic Current and ssDNA Transport through Nanopores.Biophysical journal · 2015Article
- Theory of polymer-nanopore interactions refined using molecular dynamics simulations.Journal of the American Chemical Society · 2013Article
- Molecular architecture and functional analysis of NetB, a pore-forming toxin from Clostridium perfringens.The Journal of biological chemistry · 2013Article
- A stimuli-responsive nanopore based on a photoresponsive host-guest system.Scientific reports · 2013Article
- Modeling and simulation of ion channels.Chemical reviews · 2012Review
- Translocation of a heterogeneous polymer.The Journal of chemical physics · 2012Article
- Chemical-induced pH-mediated molecular switch.Analytical chemistry · 2011Article
- Rectification of the current in alpha-hemolysin pore depends on the cation type: the alkali series probed by MD simulations and experiments.The journal of physical chemistry. C, Nanomaterials and interfaces · 2011Article
- Soft wall ion channel in continuum representation with application to modeling ion currents in α-hemolysin.The journal of physical chemistry. B · 2010Article
- Polymer translocation through alpha-hemolysin pore with tunable polymer-pore electrostatic interaction.The Journal of chemical physics · 2010Article
- Continuum electrostatic calculations of the pKa of ionizable residues in an ion channel: dynamic vs. static input structure.The European physical journal. E, Soft matter · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The current-voltage relationship of a single Staphylococcus aureus alpha-hemolysin (alphaHL) channel is nonlinear, rectifying, and depends on the bulk pH and the ionic strength. The data are described qualitatively by a simple one-dimensional Nernst-Planck analysis in which the fixed charges inside and near the pore's entrances affect the transport of ions through the channel. The distances of these fixed charges from one of the channel's entrances are obtained from the channel's crystal structure. The model demonstrates that rectification of monovalent ion flow through the alphaHL channel can be related to the asymmetry in the location of the ionizable amino acid side chains.
Indexed as
Identifiers
14724760What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.