ArticleThe Journal of membrane biology2003
Differential expression of Kir6.1 and SUR2B mRNAs in the vasculature of various tissues in rats.
Article in The Journal of membrane biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 64 citations in OpenAlex.
- Potassium channels in vascular smooth muscle cells.Physiological reviews · 2026Review
- Enzymatic Spirulina Extract Enhances the Vasodilation in Aorta and Mesenteric Arteries of Aged Rats.Marine drugs · 2025Article
- Automated patch clamp analysis of heterologously expressed Kir6.2/SUR1 and Kir6.1/SUR2B KAmerican journal of physiology. Cell physiology · 2025Article
- Characterization of four structurally diverse inhibitors of SUR2-containing KChannels (Austin, Tex.) · 2024Article
- Discovery and Characterization of VU0542270, the First Selective Inhibitor of Vascular Kir6.1/SUR2B KMolecular pharmacology · 2024Article
- The ATP sensitive potassium channel (KFrontiers in molecular neuroscience · 2023Review
- Involvement of SUR2/Kir6.1 channel in the physiopathology of pulmonary arterial hypertension.Frontiers in cardiovascular medicine · 2022Article
- Differential hyperpolarization to substance P and calcitonin gene-related peptide in smooth muscle versus endothelium of mouse mesenteric artery.Microcirculation (New York, N.Y. : 1994) · 2021Article
- Activation of the AMP-related kinase (AMPK) induces renal vasodilatation and downregulates Nox-derived reactive oxygen species (ROS) generation.Redox biology · 2020Article
- The surprising complexity of KATP channel biology and of genetic diseases.The Journal of clinical investigation · 2020Article
- Tonic regulation of middle meningeal artery diameter by ATP-sensitive potassium channels.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- KATP Channels in the Cardiovascular System.Physiological reviews · 2016Review
- Sensitivity of KATP channels to cellular metabolic disorders and the underlying structural basis.Acta pharmacologica Sinica · 2016Article
- Measuring and evaluating the role of ATP-sensitive K+ channels in cardiac muscle.Journal of molecular and cellular cardiology · 2012Review
- Role of vascular K(ATP) channels in blood pressure variability after sinoaortic denervation in rats.Acta pharmacologica Sinica · 2011Article
- Ca2+/calcineurin regulation of cloned vascular K ATP channels: crosstalk with the protein kinase A pathway.British journal of pharmacology · 2009Article
- Pinacidil induces vascular dilation and hyperemia in vivo and does not impact biophysical properties of neurons and astrocytes in vitro.Cleveland Clinic journal of medicine · 2009Article
- Expression of inwardly rectifying potassium channel subunits in native human retinal pigment epithelium.Experimental eye research · 2008Article
- K(ATP) channel expression and pharmacological in vivo and in vitro studies of the K(ATP) channel blocker PNU-37883A in rat middle meningeal arteries.British journal of pharmacology · 2008Article
- cAMP-dependent protein kinase phosphorylation produces interdomain movement in SUR2B leading to activation of the vascular KATP channel.The Journal of biological chemistry · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
ATP-sensitive K(+) channels (K(ATP)) couple the intermediary metabolism to cellular excitability and play an important role in the cardio-protective effect of ischemic preconditioning and the activity-dependent autoregulation of cerebral circulation. Although previous studies using PCR and Northern blot suggest that the vascular isoform may consist of Kir6.1 and SUR2B, their expression and precise distribution in various vasculatures remain unknown. To illustrate their vascular expression, we performed this study using in situ hybridization histochemistry. Antisense riboprobes were synthesized by in vitro transcription and labeled with digoxigenin. Distributions of these mRNAs in the various blood vessels were revealed under a bright-field microscope. The expression of Kir6.1 and SUR2B mRNAs was observed in small and intermediate arteries as well as arterioles in several tissues, including basilar, vertebral, mesenteric, coronary and renal arteries. The transcripts were found in arterial smooth muscles. Also, we observed Kir6.1/SUR2B expression in capillary beds. The Kir6.1 and SUR2B expression pattern showed clear overlap, suggesting that they may form heteromeric K(ATP) channels in these tissues. The Kir6.1 and SUR2B stains were detected in aorta and renal tubular cells although their expression level was extremely low. In contrast, the Kir6.1 and SUR2B mRNAs were not seen in vena cava, other small veins, myocardium and skeletal muscles. With their strong expression in small arteries and capillaries, it is very likely that the Kir6.1 and SUR2B form the vascular isoform of K(ATP) channels in these vasculatures.
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